Observing dengue virus infection in patients with fever
Dengue Virus Infection Amongst Patients With Acute Febrile Illness: Clinical Characteristics, Molecular and Serological Profiles for Vaccine Trial and Roll-out
This study looks at patients with fever in Indonesia to see how dengue virus affects them and to improve ways to diagnose the illness.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 400 (estimated) |
| Ages | 4 Years and up |
| Sex | All |
| Sponsor | Tangerang District Hospital Academic / other |
| Locations | 1 site (Tangerang, Banten) |
| Trial ID | NCT06255509 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the clinical characteristics, immune responses, and viral serotypes in patients diagnosed with dengue virus infection in Tangerang Regency, Indonesia. Conducted over one year, the study will focus on patients aged four years and older who present with acute febrile illness and specific dengue-like symptoms. By analyzing data from two public health centers and a district hospital, the study seeks to address the low prevalence of certain dengue serotypes and improve diagnostic methods for better patient outcomes.
Who should consider this trial
Good fit: Ideal candidates for this study are patients aged four years and older who exhibit fever and at least one dengue-like symptom.
Not a fit: Patients with conditions that may interfere with study procedures or those suspected of having focal infections may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the understanding of dengue virus infections and improve diagnostic accuracy, leading to better treatment strategies.
How similar studies have performed: While there have been studies on dengue virus infections, this specific focus on the less-reported DEN-4 serotype in a high-risk area is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients age ≥ 4 years old with fever (≥ 37.5°C), history of fever with antipyretic use, lasting less than or equal to 7 days * Presence at least one of the following dengue-like symptoms: * Headache * Retro-orbital pain * Nausea/ vomiting * Muscle, bone, or joint pain * Rash or bleeding manifestations * Patient or patient's guardian giving consent to participate in the study Exclusion Criteria: * Have a condition that may interfere with study procedures and compliance (based on doctor's assessment) * Suspected of focal infection
Where this trial is running
Tangerang, Banten
- Tangerang District Hospital — Tangerang, Banten, Indonesia (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.