Observing cardiovascular changes in patients with hypertension

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to investigate the relationship between various configurations of hypertension and the occurrence of cardiovascular events using different reference ranges. It will enroll 2,200 hypertensive patients across twenty research centers, with follow-ups at 12, 24, 36, and 48 months. Participants will undergo physical examinations, ECGs, laboratory tests, echocardiography, and carotid ultrasounds at baseline and during follow-ups. The study will analyze echocardiographic parameters to understand their correlation with cardiovascular events and prognosis in the hypertensive population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age 30-75 years old;
2. No antihypertensive drugs were used and three blood pressure measurements were conducted on different days, with systolic blood pressure ≥ 140 mmHg (1 mmHg=0.133 kPa) and/or diastolic blood pressure ≥ 90 mmHg; or have a history of hypertension and are using antihypertensive drugs, even if the blood pressure is lower than 140/90 mmHg;
3. Left ventricular ejection fraction was normal (LVEF ≥ 0.5).
4. All patients agreed to participate in the experiment and signed the informed consent form.

Exclusion Criteria:

1. Secondary hypertension caused by renal parenchymal diseases, renal vascular diseases, coarctation of aorta and endocrine system diseases;
2. Severe cardiovascular and cerebrovascular diseases; heart valve disease; persistent atrial fibrillation and severe arrhythmia; previously undergone cardiovascular disease surgery;
3. Abnormal liver function; abnormal renal function and diabetes;
4. Pregnant or breastfeeding women;
5. Expected survival time due to non-cardiovascular disease\<4 years;
6. Patients with poor echocardiographic image quality.

Where it's running

• Qilu Hospital of Shandong University
  Jinan, Shandong, China Recruiting

Study contacts

• Principal investigator: Mei Zhang, PhD — Qilu Hospital of Shandong University
• Study coordinator: Mei Zhang, PhD
• Email: daixh@vip.sina.com
• Phone: +86-18560086629

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.