Observing brain health in adults with late-onset epilepsy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The NeuroFrailty study aims to investigate the long-term effects of late-onset epilepsy by observing individuals who experience their first seizure after the age of 18. Participants will undergo various assessments, including blood tests, brain scans, and lifestyle evaluations, to track changes in memory, health, and potential new diagnoses over several years. The study seeks to determine if there is a connection between late-onset epilepsy and the risk of developing conditions such as stroke or dementia. By comparing these individuals to those without seizures, the research hopes to shed light on the implications of adult-onset epilepsy.

Why it matters

Who can join: the full rules

Inclusion criteria for case participants includes:

* diagnosis of LOE or first seizure after the age of 18.
* diagnosis confirmed or established at a tertiary neurology centre.
* sequential cases will be used; in the unlikely event that eligible cases outstrip capacity, an annual cap of the first 150 patients per year per cohort will be used.

Inclusion criteria for control participants includes:

* established diagnosis of migraine.
* with or without therapeutic medications with antiepileptic properties.

Exclusion Criteria

Exclusion criteria for case participants includes:

* a 'lesional' attributable cause for seizures including malignancy, stroke (excluding transient ischaemic attack), hypoxic brain injury, trauma, vascular or congenital abnormality of likely aetiological significance.
* people with migraine or headache syndrome can be included in case group - the presence or absence of a seizure syndrome is mutually exclusive between case and control groups, not the presence or absence of migraine.

Exclusion criteria for control participants includes:

* diagnosis of epilepsy or confirmed seizure.
* 'lesional' attributable cause for seizures including malignancy, stroke (excluding transient ischaemic attack), hypoxic brain injury, trauma.

Where it's running

• Lancashire Teaching Hospitals NHS
  Preston, Lancashire, United Kingdom Recruiting

Study contacts

• Principal investigator: Jasmine Wall, MB BChir — University of Lancaster
• Study coordinator: Jasmine Wall, MB BChir
• Email: jasmine.wall@lthtr.nhs.uk
• Phone: via switchboard

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.