Observational study on the incidence and natural course of varicose veins

Prospective Cohort Study for Varicose Veins Incidence and Natural Course

Observational Russian Phlebological Association · NCT04546750

This study looks at how varicose veins develop and change over time in people with and without them to better understand the risks and effects of this condition.

Quick facts

Study typeObservational
Enrollment100 (estimated)
Ages10 Years and up
SexAll
SponsorRussian Phlebological Association Academic / other
Locations1 site (Saint Petersburg)
Trial IDNCT04546750 on ClinicalTrials.gov

What this trial studies

This observational study aims to assess the morbidity, risk factors, and natural progression of chronic lower limb vein disease in individuals both with and without varicose veins. It involves a multicenter prospective cohort design, where participants are monitored annually through clinical and ultrasound assessments. Data is collected and maintained in a digital registry to track changes over time and identify potential risk factors associated with the development of varicose veins.

Who should consider this trial

Good fit: Ideal candidates include individuals without a history of invasive treatment for chronic venous disorders and those who can commit to annual assessments.

Not a fit: Patients with a history of venous thrombosis or previous invasive treatments for chronic venous disorders may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could enhance understanding of varicose veins and lead to improved prevention and management strategies for patients.

How similar studies have performed: While there have been studies on varicose veins, this specific prospective cohort approach focusing on the natural course and risk factors is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* A family members of the researcher (spouse, childrens, brothers and sisters, parents) or the researcher himself
* The possibility of annual clinical and ultrasound assessment of the venous system of the observed individuals

Exclusion Criteria:

* Any invasive treatment of the chronic venous disorder in anamnesis
* Venous thrombosis in the anamnesis or at the time of inclusion

Where this trial is running

Saint Petersburg

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Varicose Veins of Lower LimbThromboses, VenousVenous Insufficiency
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.