Observational study on Primary Mediastinal Large B-cell Lymphoma with CNS involvement
Retrospective Multicenter International Study on Prognostic Factors, Management And Outcome Of Primary Mediastinal Large B-Cell Lymphoma (PMLBCL) Patients With Central Nervous System (CNS) Involvement
This study is looking at patients with Primary Mediastinal Large B-cell Lymphoma who have had a relapse affecting their brain or spinal cord to see how they are treated and what their outcomes are.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 45 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | IRCCS San Raffaele Academic / other |
| Locations | 1 site (Milan) |
| Trial ID | NCT06024694 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on patients diagnosed with Primary Mediastinal Large B-cell Lymphoma (PMBCL) who have experienced a relapse involving the central nervous system (CNS). It aims to collect and analyze clinical characteristics, management strategies at diagnosis and during relapses, and patient outcomes. The study will compile data from six different countries to create a comprehensive international series on CNS involvement in PMBCL. It will also include a central pathological review of initial diagnoses and relapses when available.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older with a histologically confirmed diagnosis of PMBCL who have experienced CNS involvement.
Not a fit: Patients with CNS lymphoma of a subtype other than PMBCL will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of PMBCL with CNS involvement, leading to improved treatment strategies and outcomes for affected patients.
How similar studies have performed: While this study focuses on a specific aspect of PMBCL, similar observational studies have shown success in gathering valuable data on rare cancers, suggesting potential for meaningful insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Histologically confirmed diagnosis of Primary Mediastinal Large B Cell Lymphoma (PMLBCL) according WHO Classification * Had a recurrence/progression with Central Nervous System (CNS) involvement * Availability of details on clinical presentation, treatment details and outcome * Availability of details on pathological data for central review * Age ≥18 years Exclusion Criteria * Patients with CNS lymphoma other than PMLBCL subtype
Where this trial is running
Milan
- Ospedale San Raffaele — Milan, Italy (Recruiting)
Study contacts
- Study coordinator: Andres Ferreri
- Email: ferreri.clinicaltrials@hsr.it
- Phone: 0226435603
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.