Clinical trial Recruiting at 4 sites Observational Ages 18 and up

Observational study on managing large colorectal polyps

Official title: The St. Paul's Hospital Advanced Endoscopic Resection Centre Cohort for Colorectal Neoplasia (SPARC-C): A Prospective Observational Study

Run by University of British Columbia · NCT05402696 · Data updated 2026-11-12

This study is trying to see how well different endoscopic methods work for treating large colorectal polyps in patients over the next 10 years.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment3500 (estimated)
SponsorUniversity of British Columbia
Academic / other
Locations6 sites (Saint Cloud, Minnesota and 5 other locations)
StatusRecruiting
StartedJune 27, 2022
Main results expectedDecember 31, 2032
Study endsDecember 31, 2032
Registry record updatedMay 15, 2026
Trial IDNCT05402696 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults aged 18 and older who have been referred for the management of large non-pedunculated colorectal polyps.

Probably not a fit

Patients who are unable to provide informed consent or are pregnant or lactating will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The SPARC-C study is a prospective observational study focusing on patients referred for the management of large non-pedunculated colorectal polyps (LNPCPs). It aims to collect comprehensive data on patient demographics, lesion characteristics, procedural details, and clinical outcomes related to endoscopic resection techniques. The study will evaluate the effectiveness and safety of various endoscopic methods, including endoscopic mucosal resection and endoscopic submucosal dissection, over a period of 10 years with a target enrollment of 3500 participants. This research will help refine management strategies and improve patient outcomes in colorectal neoplasia.

Why it matters

Potential benefit: If successful, this study could enhance the management and treatment outcomes for patients with large colorectal polyps, potentially reducing the need for surgical interventions.

How similar studies have gone: Other studies have shown success with similar endoscopic approaches for managing colorectal polyps, indicating that this methodology is both established and promising.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients ≥ 18 years of age referred for the management of an LNPCP
* Able to provide informed consent.

Exclusion Criteria:

* Unable to provide informed consent
* Pregnant or lactating women.

Where it's running

  • St. Cloud Hospital
    Saint Cloud, Minnesota, United States
    Recruiting
  • Vancouver General Hospital
    Vancouver, British Columbia, Canada
    Recruiting
  • St. Paul's Hospital
    Vancouver, British Columbia, Canada
    Recruiting
  • Pacific Gastroenterology Associates
    Vancouver, British Columbia, Canada
    Recruiting
  • Mount Saint Joseph Hospital
    Vancouver, British Columbia, Canada
    Active not recruiting
  • Hadassah Ein Kerem Hospital
    Jerusalem, Israel
    Active not recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.