Observational study of patients with monoclonal gammopathy of undetermined significance

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to monitor patients diagnosed with monoclonal gammopathy of undetermined significance (MGUS) to better understand its progression and complications. MGUS is a precursor condition to multiple myeloma, which affects a significant number of older adults. The study will collect data on patients' health status, diagnostic delays, and any clinical complications that arise, with the goal of improving early detection and management of myeloma. By following patients over time, researchers hope to identify patterns that could lead to better outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

• Any individual with a confirmed or suspected case of MGUS

Exclusion Criteria:

* Those who are unable or unwilling to give informed consent
* Patients under the age of 18
* Patients with no evidence of MGUS
* Patients with a light chain ratio of 0.3 to 3.0 without a monoclonal protein on serum electrophoresis or immunofixation
* Patients with rapidly rising paraprotein or serum free light chains of progressive disease at time of diagnosis or inclusion into study

Where it's running

• Secure Study
  Oxford, Oxfordshire, United Kingdom Recruiting

Study contacts

• Principal investigator: Karthik Ramasamy — Oxford University Hospitals NHS Trust
• Study coordinator: Richard Brouwer, BSc
• Email: richard.brouwer@ouh.nhs.uk
• Phone: 07594301699

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• How N-glycosylation of light chains affects AL amyloidosis diagnosis and treatment

  This project will test whether a sugar modification called N-glycosylation on immunoglobulin light chains helps cause disease or changes how AL amyloidosis and related monoclonal gammopathies behave in adults.

  Recruiting Fondazione IRCCS Policlinico San Matteo di Pavia · Pavia, PV · NCT07448779

• Investigating gut microbiota and immune function in monoclonal gammopathy patients

  This study looks at the gut bacteria and immune system in patients with monoclonal gammopathy to see how they might be affected, especially in those with infections.

  Recruiting Zhujiang Hospital · Guanzhou, Guangdong · NCT06539832

• Collection and analysis of biological samples from patients with multiple myeloma and related conditions

  This study is collecting and storing blood samples from patients with multiple myeloma and similar conditions to help researchers learn more about these diseases and improve treatments.

  Recruiting at 41 sites European Myeloma Network B.V. · Melbourne and 40 other locations · NCT06237803

• Multi-omics profiling to predict progression from MGUS and smoldering myeloma to symptomatic multiple myeloma

  This project will try to see if combined genomic, immune, and oral microbiome tests can predict which people with MGUS or smoldering myeloma will progress to symptomatic multiple myeloma.

  Recruiting Azienda USL Reggio Emilia - IRCCS · Bologna and 3 other locations · NCT07214324

• Analyzing gut microbiota in patients with monoclonal gammopathy

  This study is trying to see how the gut bacteria of people with monoclonal gammopathy differ from those without the condition to help find new ways to diagnose and treat it.

  Recruiting Zhujiang Hospital · Guanzhou, Guangdong · NCT06690593

• Identifying precancerous multiple myeloma in African American adults

  This study is testing a way to find early signs of multiple myeloma in Black and African American adults aged 30 and older to help catch it sooner and improve their health outcomes.

  Recruiting Wake Forest University Health Sciences · Charlotte, North Carolina · NCT06644625

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.