Observational study of patients with ATTR amyloidosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to describe the epidemiological and clinical characteristics of patients with transthyretin-mediated amyloidosis (ATTR amyloidosis). It will also evaluate the safety and effectiveness of existing treatments, patisiran and vutrisiran, in real-world clinical settings. Additionally, the study will monitor disease progression in individuals who are pre-symptomatic carriers of known disease-causing TTR variants. The research will be conducted in Germany and select sites in the United States.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of ATTR amyloidosis or documented known disease-causing TTR variant for the cohort of pre-symptomatic carriers
* Germany Only: Patients must be treated per the summary of product characteristics (SmPC) for any approved treatment for ATTR amyloidosis

Exclusion Criteria:

* Current enrollment in a clinical trial for any investigational agent

Where it's running

• Clinical Trial Site
  La Jolla, California, United States Recruiting
• Clinical Trial Site
  Los Angeles, California, United States Recruiting
• Clinical Trial Site
  Jacksonville, Florida, United States Recruiting
• Clinical Trial Site
  Iowa City, Iowa, United States Recruiting
• Clinical Trial Site
  Kansas City, Kansas, United States Recruiting
• Clinical Trial Site
  Baltimore, Maryland, United States Recruiting

Study contacts

• Study coordinator: Alnylam Clinical Trial Information Line
• Email: clinicaltrials@alnylam.com
• Phone: 1-877-ALNYLAM

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Hungarian National Systemic Amyloidosis Registry

  This registry collects medical data from adults with systemic amyloidosis across Hungary to help understand how the disease is diagnosed and treated in real-world practice.

  Recruiting at 12 sites Semmelweis University · Balatonfüred and 11 other locations · NCT07689331

• Understanding the characteristics and treatment of patients with ATTR amyloidosis

  This study is looking to understand the experiences and treatments of people with ATTR amyloidosis to see how the disease affects their lives and how it is managed over time.

  Recruiting at 5 sites AstraZeneca · Eden Prairie, Minnesota and 28 other locations · NCT06355934

• Registry for patients with ATTR amyloidosis

  This study is creating a detailed registry for people with ATTR amyloidosis to track their health over time and help doctors understand the disease better.

  Recruiting Fondazione IRCCS Policlinico San Matteo di Pavia · Legnano, MI and 29 other locations · NCT05444920

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.