Observational study of monkeypox infection in Brazil
Observational, Prospective, Cohort Study of Mpox Infection in Brazil - NETPOX Cohort
This study is trying to see how different health factors affect the risk and severity of monkeypox in people in Brazil.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 80 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Hospital Israelita Albert Einstein Academic / other |
| Locations | 3 sites (Belém, Pará and 2 other locations) |
| Trial ID | NCT05784038 on ClinicalTrials.gov |
What this trial studies
This study is a prospective cohort investigation that aims to evaluate clinical and immune-metabolic factors associated with the risk and severity of monkeypox infection in Brazil. It plans to enroll at least 80 patients over a six-month period, with follow-up assessments conducted through decentralized visits for 90 days post-inclusion. The study will utilize viral genomic analysis and untargeted metabolomics to gather data on the infection's impact.
Who should consider this trial
Good fit: Ideal candidates include men and women aged 18 years and older with confirmed monkeypox infection.
Not a fit: Patients unable to provide informed consent or those deemed unsuitable for decentralized follow-up may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of monkeypox infection and improve management strategies for affected patients.
How similar studies have performed: While there have been studies on monkeypox, this specific observational approach focusing on immune-metabolic variables is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Men and women aged ≥ 18 years with confirmed MPOX infection. (laboratory-confirmed monkeypox infection is defined as determined by PCR, culture, or antigen test obtained from a sample collected from blood, oropharynx, anal or skin lesion within 4 days of randomization) Exclusion Criteria: * Inability to provide informed consent; * Patient who, judging by the study team, does not have a condition for decentralized follow-up
Where this trial is running
Belém, Pará and 2 other locations
- Hospital Universitário João de Barros Barreto — Belém, Pará, Brazil (Recruiting)
- Hospital Israelita Albert Einstein — São Paulo, São Paulo, Brazil (Recruiting)
- Hospital Naval Marcílio Dias — Rio de Janeiro, Brazil (Recruiting)
Study contacts
- Study coordinator: Henrique AR Fonseca, PhD
- Email: henrique.fonseca@einstein.br
- Phone: +5511968308958
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.