Clinical trial Recruiting at 1 site Observational Ages 18 and up

Observational study of iris tumors using imaging techniques

Official title: Observational Study of Iris Tumors

Run by Oregon Health and Science University · NCT03809585 · Data updated 2026-11-12

This study is trying to learn more about iris tumors by using special imaging techniques to compare them with healthy eyes in people who have these tumors and those who don’t.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment100 (estimated)
SponsorOregon Health and Science University
Academic / other
Locations1 site (Portland, Oregon)
StatusRecruiting
StartedJune 20, 2018
Main results expectedDecember 2026
Study endsDecember 2027
Registry record updatedSeptember 9, 2025
Trial IDNCT03809585 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include individuals with diagnosed melanotic or amelanotic iris tumors and healthy individuals without iris defects.

Probably not a fit

Patients with concurrent retinal diseases, glaucoma, or those unable to provide informed consent may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study utilizes Optical Coherence Tomography (OCT) angiography to characterize melanotic and amelanotic iris tumors by comparing imaging data from affected eyes to healthy controls. The study aims to enhance understanding of iris tumors and their vascular characteristics. Participants include individuals diagnosed with iris tumors as well as healthy individuals without any iris lesions. The study will not involve any treatments or interventions, focusing solely on data collection and analysis.

Why it matters

Potential benefit: If successful, this study could improve diagnostic accuracy and management strategies for patients with iris tumors.

How similar studies have gone: While there have been studies using OCT in other ocular conditions, this specific approach to iris tumors is relatively novel and untested.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria for tumor group:

* Eyes with diagnosis of melanotic or amelanotic iris tumors

Inclusion Criteria for healthy control group:

* Eyes without iris defects or lesions

Exclusion Criteria (both groups):

* Inability to give informed consent
* Inability to maintain stable fixation for OCT imaging
* Inability to commit to required study visits
* Eyes with concurrent retinal diseases, glaucoma, or conditions that in the opinion of the investigators might affect iris circulation
* Mature cataracts if found to limit visual potential to worse than 20/40

Where it's running

  • Oregon Health & Science University
    Portland, Oregon, United States
    Recruiting

Study contacts

  • Principal investigator: David Huang, MD, PhD — Oregon Health and Science University
  • Study coordinator: Denzil Romfh, OD
  • Email: romfhd@ohsu.edu
  • Phone: 503-494-4351

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.