Observational study of iris tumors using imaging techniques
Official title: Observational Study of Iris Tumors
Run by Oregon Health and Science University · NCT03809585 · Data updated 2026-11-12
This study is trying to learn more about iris tumors by using special imaging techniques to compare them with healthy eyes in people who have these tumors and those who don’t.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Oregon Health and Science University Academic / other |
| Locations | 1 site (Portland, Oregon) |
| Status | Recruiting |
| Started | June 20, 2018 |
| Main results expected | December 2026 |
| Study ends | December 2027 |
| Registry record updated | September 9, 2025 |
| Trial ID | NCT03809585 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals with diagnosed melanotic or amelanotic iris tumors and healthy individuals without iris defects.
✕Probably not a fit
Patients with concurrent retinal diseases, glaucoma, or those unable to provide informed consent may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study utilizes Optical Coherence Tomography (OCT) angiography to characterize melanotic and amelanotic iris tumors by comparing imaging data from affected eyes to healthy controls. The study aims to enhance understanding of iris tumors and their vascular characteristics. Participants include individuals diagnosed with iris tumors as well as healthy individuals without any iris lesions. The study will not involve any treatments or interventions, focusing solely on data collection and analysis.
Why it matters
Potential benefit: If successful, this study could improve diagnostic accuracy and management strategies for patients with iris tumors.
How similar studies have gone: While there have been studies using OCT in other ocular conditions, this specific approach to iris tumors is relatively novel and untested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria for tumor group: * Eyes with diagnosis of melanotic or amelanotic iris tumors Inclusion Criteria for healthy control group: * Eyes without iris defects or lesions Exclusion Criteria (both groups): * Inability to give informed consent * Inability to maintain stable fixation for OCT imaging * Inability to commit to required study visits * Eyes with concurrent retinal diseases, glaucoma, or conditions that in the opinion of the investigators might affect iris circulation * Mature cataracts if found to limit visual potential to worse than 20/40
Where it's running
-
Oregon Health & Science University
Portland, Oregon, United States Recruiting
Study contacts
- Principal investigator: David Huang, MD, PhD — Oregon Health and Science University
- Study coordinator: Denzil Romfh, OD
- Email: romfhd@ohsu.edu
- Phone: 503-494-4351
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Topical ruxolitinib for adults with pyoderma gangrenosum
This pilot study tests a topical cream of ruxolitinib to see if it helps heal PG ulcers in adults without adding systemic immunosuppressants.
-
Bright light therapy to help sleep after brain injury
This trial tests whether morning bright light therapy can improve sleep and related brain health markers in adults with a traumatic brain injury.
-
Transitioning from mavacamten to aficamten in obstructive HCM
This study tests whether switching from mavacamten to aficamten is feasible and safe for people with obstructive hypertrophic cardiomyopathy who are already on mavacamten.
-
Motor Activation Therapy after concussion: a targeted rehabilitation approach
This study tests a motor-activation focused physical therapy for people with persistent balance problems after a concussion to see if it improves their responses to imbalance.
-
L-fucose supplementation for adults with GLUT1 deficiency
This trial will test whether taking L-fucose supplements helps reduce ataxia and other symptoms in adults with GLUT1 deficiency.
-
Cefotetan Therapy for E. coli Infections
This pilot study tests whether cefotetan works for bloodstream infections caused by E. coli, compared with standard antibiotics, to see if it improves outcomes.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.