Observational study of healthcare workers' immunity to COVID-19
Official title: Health Care Workers Cohort Study in the EuCARE Project (EuCARE-HCW)
Run by Euresist Network GEIE · NCT05534009 · Data updated 2026-11-12
This study looks at how long and how well healthcare workers' immunity to COVID-19 lasts after vaccination or infection, while also checking if new virus variants can dodge that immunity.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1800 (estimated) |
| Sponsor | Euresist Network GEIE Academic / other |
| Locations | 7 sites (Düsseldorf and 6 other locations) |
| Status | Recruiting |
| Started | April 1, 2022 |
| Main results expected | December 15, 2025 |
| Study ends | December 15, 2025 |
| Registry record updated | September 19, 2025 |
| Trial ID | NCT05534009 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adult healthcare workers over 18 years old with documented vaccination or SARS-CoV-2 infection status.
✕Probably not a fit
Patients who do not work in healthcare or do not have a history of vaccination or SARS-CoV-2 infection may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The EuCARE-HCW study is an observational multicentre project that collects both retrospective and prospective data from healthcare workers who have either been vaccinated against COVID-19 or have had a confirmed SARS-CoV-2 infection. Participants will provide biological samples periodically over 12-24 months to analyze the impact of different viral variants on immunity. The study aims to understand the duration and breadth of immunity following vaccination and natural infection, as well as the potential for vaccine escape by various SARS-CoV-2 variants. This research involves collaboration across eight countries, enhancing the diversity of data collected.
Why it matters
Potential benefit: If successful, this study could provide valuable insights into the effectiveness of COVID-19 vaccines and natural immunity, potentially guiding future vaccination strategies.
How similar studies have gone: Other studies have shown success in analyzing immunity to COVID-19 variants, making this approach both relevant and necessary.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: The study subjects will be selected based on the following inclusion criteria: 1. Adult (\>18 years) HCW with mandatory information on their SARS-CoV-2 infection and vaccination status. 2. For those with a history of SARS-CoV-2 infection, diagnosis obtained by detection of SARS-CoV-2 RNA 3. Having a signed informed consent when required by ethical approval Exclusion Criteria: NONE
Where it's running
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Heinrich Heine university
Düsseldorf, Germany Recruiting -
Azienda Socio-Sanitaria Territoriale Santi Paolo e Carlo
Milan, Italy Recruiting -
Ieo Istituto Europeo Di Oncologia
Milan, Italy Recruiting -
Viesoji Istaiga Vilniaus Uiversiteto Ligoninė Santaros klinikos
Vilnius, Lithuania Recruiting -
Hospital Juan Ghaham Casasus
Villahermosa, Mexico Recruiting -
Centro Hospitalar de Lisboa Ocidental
Lisbon, Portugal Recruiting
Show 1 more location
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Bach Mai Hospital
Hanoi, Vietnam Recruiting
Study contacts
- Study coordinator: Francesca Incardona, Dr
- Email: francesca.incardona@euresist.org
- Phone: +393356112830
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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COVID-19 Registry at San Matteo (SMACORE) - patient-matching observational registry
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MDX2301 in healthy adults and adults at higher risk for severe COVID-19
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.