Clinical trial Recruiting at 3 sites Observational Ages 18 to 130

Observational look at how adults with stomach and GEJ cancer are diagnosed and treated in Greece

Official title: Epidemiological Characteristics And Management Strategies Of Gastric/Gastrophaegal Junction Cancer Patients In Routine Clinical Practice: A Greek Multicenter Observational Study (The GRACE Study)

Run by AstraZeneca · NCT07800754 · Data updated 2026-11-12

This study will look at real-world care for adults with stage II-IVB gastric or gastroesophageal junction cancer in Greece to see how they are diagnosed and managed in usual practice.

Quick facts

Study typeObservational
Ages18 Years to 130 Years
SexAll
Enrollment300 (estimated)
SponsorAstraZeneca
Industry-sponsored
Locations9 sites (Alexandroupoli and 8 other locations)
StatusRecruiting
StartedSeptember 30, 2026
Main results expectedDecember 31, 2027
Study endsDecember 31, 2027
Registry record updatedNovember 9, 2026
Trial IDNCT07800754 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults 18 years or older with histologically confirmed stage II to IVB gastric or GEJ adenocarcinoma diagnosed between June 1, 2025 and the end of the recruitment period (Q3 2027).

Probably not a fit

Patients who have concurrent primary cancers requiring systemic treatment or who participate in interventional trials may not directly benefit from this observational study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter, Greece-only observational study collects retrospective and prospective data to describe epidemiology and management patterns of stage II-IVB gastric/GEJ adenocarcinoma in routine clinical care. It is non-interventional and seeks to document outcomes as patients undergo standard treatment chosen by their clinicians. Participation is voluntary and can be withdrawn at any time, with efforts made to capture outcomes. The study is sponsored by AstraZeneca and involves several Greek research sites. Data collection spans from June 1, 2025 through the end of the recruitment period in Q3 2027.

Why it matters

Potential benefit: Findings could help understand real-world treatment patterns and outcomes to inform future care for gastric/GEJ cancer patients in Greece.

How similar studies have gone: Real-world observational studies in gastric cancer have provided valuable insights into treatment patterns and outcomes in other settings, supporting the relevance of this approach in Greece.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients aged ≥18 years upon gastric/GEJ adenocarcinoma diagnosis.
* Written signed and dated informed consent by the patient (or their legally acceptable representative, as applicable). For deceased patients on the date of study entry a waiver of consent must be approved by the Hospital EC/IRB.
* Patients diagnosed with histologically confirmed, stage II to IVB adenocarcinoma of gastric/GEJ, between June 1st, 2025 and the end of the recruitment period (Q3 2027).

Exclusion Criteria:

* Patients who participate or participated during the data collection period (prospective and retrospective) in any clinical investigation/clinical trial that includes interventions that fall outside the everyday clinical practice.
* Patients who have participated in the design and/or the conduct of the study.
* Patients with another primary malignancy within the last 5 years, for which systemic anticancer treatment is required after the diagnosis of gastric/GEJ cancer.

Where it's running

  • Research Site
    Athens, Greece
    Recruiting
  • Research Site
    Crete, Greece
    Recruiting
  • Research Site
    Thessaloniki, Greece
    Recruiting
  • Research Site
    Alexandroupoli, Greece
    Not yet recruiting
  • Research Site
    Athens, Greece
    Not yet recruiting
  • Research Site
    Athens, Greece
    Withdrawn
Show 3 more locations
  • Research Site
    Ioannina, Greece
    Not yet recruiting
  • Research Site
    Pátrai, Greece
    Not yet recruiting
  • Research Site
    Thessaloniki, Greece
    Not yet recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.