Observational cohort for Adult Onset Still Disease and Systemic onset Juvenile Idiopathic Arthritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational cohort study focuses on Adult Onset Still Disease (AOSD) and Systemic onset Juvenile Idiopathic Arthritis (SoJIA), two rare inflammatory diseases that share similar symptoms and diagnostic criteria. The study aims to collect clinical and biological data from affected patients to better understand the disease's characteristics and progression. Participants will be monitored for symptoms such as fever, arthritis, and skin rash, and their inflammatory markers will be analyzed. The study will include both adults and children diagnosed with these conditions, providing valuable insights into their management and treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged over 16 (age\> 16) meeting the diagnostic criteria of Yamaguchi or Fautrel criteria (appendix 5)
* Aged 16 years or less (age ≤16 years) fulfilling the 2001 criteria for ILAR systemic form of juvenile idiopathic arthritis
* Having signed a consent to participate in the cohort and in the collection of clinical and biological data; in accordance with the regulations, for patients who are minors or adults who are protected, the non-opposition of the legal representatives will be sought.
* Affiliated to the "Régime National d'Assurance Maladie".

Exclusion Criteria:

* Other cause of relapsing infectious fever (such as tuberculosis, toxoplasmosis, deep abscesses, viroses, sepsis) or tumor (such as lymphomas)
* Other defined inflammatory rheumatism such as rheumatoid arthritis, psoriatic arthritis, spondyloarthropathies.
* Autoimmune inflammatory disease (systemic lupus erythematosus), granulomatosis (sarcoidosis, Blau syndrome), vasculitis (Behçet's disease, nodular arteritis), polymyositis and dermatomyositis.
* Well-defined auto-inflammatory syndromes with unambiguous mutations, such as familial Mediterranean fever, cryopyrinopathies, TRAPS, mevalonate kinase deficiency.
* Known macrophage activation syndromes of genetic origin.
* Patients unable to understand the information leaflet and sign the informed consent form
* Patients not affiliated to the "Régime National d'Assurance Maladie"

Where it's running

• RaDiCo-AcoStill
  Paris, Île-de-France Region, France Recruiting

Study contacts

• Principal investigator: Sophie Georgin-Lavialle, PHD — Inserm U933
• Study coordinator: Sophie Georgin-Lavialle, PHD
• Email: sophie.georgin-lavialle@aphp.fr
• Phone: 0033 156017447

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.