Nutritional support to reduce postoperative delirium in elderly patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study is a prospective, single-center, randomized controlled trial aimed at evaluating the effects of nutritional supplementation therapy on elderly patients aged 65 and older who are undergoing non-cardiac surgery. The trial will compare a control group with a group receiving nutritional support before and after surgery to determine if this intervention can lower the incidence of postoperative delirium. Participants must be able to take oral intake starting from the first postoperative day and are expected to undergo surgeries lasting two hours or more under general anesthesia.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Elderly patients aged 65 and above.
* Patients undergoing non-cardiac major surgery in thoracic surgery, lung cancer surgery, multi-level spinal surgery in neurosurgery and orthopedics, or liver cancer surgery in hepatobiliary and pancreatic surgery, under general anesthesia with an expected surgery duration of 2 hours or more.
* Patients scheduled for arterial catheterization.
* Patients who are able to take oral intake from postoperative day #1.

Exclusion Criteria:

* Patients with uncontrolled systemic conditions such as diabetes, hypertension, renal disease, liver disease, and other systemic illnesses.
* Those with visual impairment.
* Patients with cognitive impairment based on the Mini-Mental State Examination for Dementia Screening criteria.
* Individuals experiencing difficulty in communication.
* Those diagnosed with neurological disorders (such as brain hemorrhage, stroke, brain tumor, dementia, Parkinson's disease, cognitive impairment, depression, etc.).
* Patients diagnosed with alcohol or substance addiction.
* Patients with cancelled scheduled surgeries.
* Patients undergoing minor surgeries with expected anesthesia durations of less than 2 hours.

Where it's running

• Yonsei University Health system, Severance Hospital
  Seoul, South Korea Recruiting

Study contacts

• Study coordinator: Bon-Nyeo koo, MD
• Email: koobn@yuhs.ac
• Phone: 82-10-9982-4469

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.