Nutrition and metabolic profiling in people with lung cancer to create personalized diet plans
LISTENING: Unveiling Malnutrition and Metabolic Changes in Lung Cancer Patients: Setting the Basis for Precision Nutrition Models. The Listenig Nutritional Study is Part of the Project MENTORING (Project ID: 101162297; Call: HORIZON-EIC-2023-PATHFINDERCHALLENGES-01; Programme: HORIZON; DG/Agency: EISMEA; Title: Addressing Malnutrition and Metabolic Health in Non-communicable Diseases Through Precision Nutrition: Impact in Quality of Life and Prognosis of Lung Cancer Patients)
This project will collect health, nutrition, and metabolic data from adults with lung cancer and healthy volunteers to try to build personalized nutrition recommendations.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 180 (estimated) |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Sponsor | Fundación Investigación E Innovación Biomédica Hospital Universitario Infanta Sofia-Henares Academic / other |
| Drugs / interventions | chemotherapy, immunotherapy |
| Locations | 3 sites (Parma, Parma and 2 other locations) |
| Trial ID | NCT07486947 on ClinicalTrials.gov |
What this trial studies
This observational study will gather clinical, nutritional, and metabolic information from adults with non-small cell and small cell lung cancer across multiple centers, alongside a cohort of healthy volunteers as controls. Participants aged 18–85 will include people receiving chemotherapy, immunotherapy, combination or biological therapies, conservative care, or no active treatment, with exclusions for uncontrolled chronic disease or acute gastrointestinal illness. Collected data will be used to characterize nutritional impairment patterns and metabolic changes associated with lung cancer and its treatments. The goal is to use these patterns to develop a precision nutrition model that can suggest individualized dietary strategies.
Who should consider this trial
Good fit: Adults aged 18–85 with a diagnosis of non-small cell or small cell lung cancer, regardless of current treatment status, are the intended participants for the patient cohort.
Not a fit: People with uncontrolled chronic diseases or acute gastrointestinal conditions are excluded and would not be eligible to participate or benefit from this protocol.
Why it matters
Potential benefit: If successful, the project could enable tailored dietary recommendations that reduce malnutrition and improve health outcomes for people with lung cancer.
How similar studies have performed: Previous observational work has documented nutritional deficits in cancer patients and pilot personalized nutrition approaches have shown promise, but comprehensive precision nutrition models specific to lung cancer remain limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria • Study population cohort: Patients of both sexes Patients aged between 18 and 85 years Patients diagnosed with lung cancer (non-small cell and small cell) Patients treated with chemotherapy, immunotherapy, combinations of immunotherapy and biological therapy, patients receiving conservative therapy, without active treatment, or any other type of treatment, according to ESMO and NCCN guidelines for the management of metastatic lung cancer (small cell and non-small cell) • Control population cohort: Volunteers of both sexes Volunteers aged between 18 and 85 years Volunteers free of oncological disease Exclusion Criteria • Study population cohort: Patients with uncontrolled chronic diseases Patients with acute gastrointestinal diseases • Control population cohort: Volunteers with uncontrolled chronic diseases Volunteers with acute gastrointestinal diseases Volunteers who have had any type of oncological condition at any point in their lives Volunteers with diagnosed pulmonary pathology: chronic lung disease, asthma, pulmonary fibrosis, bronchiectasis, interstitial lung disease, recent pneumonia (3-6 months), moderate/severe sleep apnea, latent or previous tuberculosis with sequelae Volunteers with underlying autoimmune diseases: rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis Volunteers with active or chronic infections: HIV, hepatitis B or C, recurrent chronic infections, tuberculosis
Where this trial is running
Parma, Parma and 2 other locations
- University Hospital of Parma — Parma, Parma, Italy (Recruiting)
- IMDEA Nutrition — Madrid, Madrid, Spain (Recruiting)
- Infanta Sofía University Hospital — San Sebastián de los Reyes, Madrid, Spain (Recruiting)
Study contacts
- Study coordinator: Juan Moreno Rubio
- Email: jmrubio@salud.madrid.org
- Phone: +34911914164
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.