Nurse-led program to prevent complications from long-term corticosteroid use
Official title: Evaluation of a Nurse-led Program for the Prevention of Complications of Long-term Corticosteroid Therapy
Run by University Hospital, Brest · NCT04909606 · Data updated 2026-11-12
This study tests a nurse-led program to help adults using long-term corticosteroids avoid complications like osteoporosis and infections.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 191 (estimated) |
| Sponsor | University Hospital, Brest Academic / other |
| Locations | 5 sites (Brest and 4 other locations) |
| Status | Recruiting |
| Started | April 26, 2022 |
| Main results expected | October 26, 2028 |
| Study ends | October 26, 2028 |
| Registry record updated | March 20, 2026 |
| Trial ID | NCT04909606 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 or older who are initiating corticosteroid therapy within 30 days and have a cumulative dosage of at least 2000 mg.
✕Probably not a fit
Patients who have previously been exposed to long-term corticosteroids or those with severe chronic renal failure or organ transplant history may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates a nurse-led prevention program aimed at reducing complications associated with long-term corticosteroid therapy in adult patients. It employs a Prospective Randomized Open trial with a Blind Evaluation (PROBE) design, where participants will be assessed at baseline and after 52 weeks. The program focuses on preventing adverse effects such as osteoporosis, infections, and adrenal insufficiency through tailored interventions including vaccinations, physical activity promotion, and dietary management. The effectiveness of the program will be measured using clinical evaluations, routine biology tests, and quality of life assessments.
Why it matters
Potential benefit: If successful, this program could significantly reduce the adverse effects of long-term corticosteroid therapy, improving patient quality of life.
How similar studies have gone: While nurse-led prevention programs for other therapies have shown success, this specific approach for long-term corticosteroid therapy is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 18 or older * Initiation of corticosteroids within 30 days prior to inclusion * Estimated cumulative dosage of corticosteroids ≥ 2000 mg * Affiliated member of the social security system Exclusion Criteria: * Patients unable to give consent or unable to understand the protocol * A patient who is not 'or is no longer' able to communicate remotely by telephone could not 'or no longer' be included in the study. * Patients under guardianship * Previous exposure to long-term corticosteroids * Prescription of corticosteroids for the management of malignant neoplasms * Severe chronic renal failure with clearance of creatinine \< 30 ml/min. * History of organ transplantation * Pregnant or breastfeeding women
Where it's running
-
CHU Brest
Brest, France Recruiting -
CH La Rochelle
La Rochelle, France Recruiting -
CH Le Puy en Velay
Le Puy-en-Velay, France Recruiting -
CH Le Mans
Le Mans, France Enrolling by invitation -
CH de Morlaix
Morlaix, France Enrolling by invitation
Study contacts
- Study coordinator: Solen NICOL
- Email: solen.nicol@chu-brest.fr
- Phone: +33298145015
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Unified care and integrated treatments for ADHD with substance use in prison settings
Aimed at people under correctional supervision who have ADHD and substance use disorder, this program tests a coordinated care approach to improve identification and support.
-
4D dynamic LAFOV FDG-PET to tell leftover cancer from post-radiation inflammation in head and neck squamous cell carcinoma
This study will test whether a 4D dynamic long‑axial‑field‑of‑view FDG‑PET scan can tell remaining head and neck squamous cell cancer from normal post‑radiation inflammation in adults about three months after finishing curative radiotherapy.
-
Imaging the anatomy of the eye socket (orbit)
This project looks at existing orbital imaging from adults to see how the eye muscles, optic nerve, and orbital fat are arranged.
-
Combining European cohort data to find biomarkers that guide treatment for venous thromboembolism
This project combines clinical, biological and imaging data from European patient cohorts to try to find biomarkers that predict clot recurrence, bleeding, or death in people with venous thromboembolism.
-
Deneo Kid: an app to coordinate rehabilitation care for children and young people with neuromotor disabilities
This project will test whether the Deneo Kid app helps children and young people (age 2–25), their families, and rehabilitation teams share information and coordinate care more easily over three months.
-
Joint tissue analysis to understand rare and immunotherapy-related inflammatory arthritis
This project tests whether analyzing joint biopsy tissue can reveal distinct immune features in adults with inflammatory arthritis linked to rare autoimmune diseases or caused by cancer immunotherapy.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.