Novel method for targeted brain stimulation
T-REEX: Phase Locked TRanscranial Electrical EXcitation
NA · Stichting IMEC-NL · NCT05847829
This study is testing a new way to use brain stimulation that targets specific brain waves to see if it works better than older methods for people who might benefit from non-invasive treatments.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 10 (estimated) |
| Ages | 18 Years to 64 Years |
| Sex | All |
| Sponsor | Stichting IMEC-NL (other) |
| Locations | 1 site (Heeze, Noord Brabant) |
| Trial ID | NCT05847829 on ClinicalTrials.gov |
What this trial studies
This study explores a new approach to transcranial current stimulation (tCS) that aims to enhance the precision of brain stimulation by using a closed-loop system. By phase-locking the stimulation to specific brain waves, the study seeks to improve the effectiveness of non-invasive brain stimulation techniques. Participants will undergo stimulation using the T-REEX algorithm, which is designed to selectively target brain activity in both space and time. The goal is to demonstrate that this method can provide better control over stimulation effects compared to traditional open-loop configurations.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 to 64 who can provide informed consent and do not have any contraindications.
Not a fit: Patients with known neurological disorders, active implants, or skin sensitivities at the stimulation site may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to more effective non-invasive treatments for various neurological conditions.
How similar studies have performed: While the concept of closed-loop brain stimulation is gaining interest, this specific approach using the T-REEX algorithm is relatively novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Signed informed consent * Age between 18 and 64 Exclusion Criteria: * Wounded or particular sensitive skin at areas of investigation. For example, skinrash, discoloration, scars, or open wounds * Allergies to adhesive or dry electrodes or silver chloride * Pregnant or lactating * Any of the following symptoms (fever, tiredness, dry cough, aches and pains, nasal congestion, runny nose, sore throat, diarrhoea) * Known neurological disorders * Previous epileptic episodes * Active implants such as pacemakers or brain stimulators * Intracranial metal implants
Where this trial is running
Heeze, Noord Brabant
- Stichting Kempenhaeghe — Heeze, Noord Brabant, Netherlands (RECRUITING)
Study contacts
- Principal investigator: Raf van Hoof, PhD — Stichting Kempenhaeghe
- Study coordinator: Raf van Hoof, PhD
- Email: HoofR@kempenhaeghe.nl
- Phone: 0031 40 227 92 04
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Novel Method for Transcranial Brain Stimulation, Brain stimulation, Closed-loop, Brain activity