Clinical trial Recruiting at 1 site Observational Ages Any age to 20

Normal hormone levels in children measured by LC‑MS/MS

Official title: Determining Paediatric Usual Values for Hormones Dosages by Mass Spectrometry

Run by Assistance Publique - Hôpitaux de Paris · NCT06694415 · Data updated 2026-11-12

This project will try LC‑MS/MS hormone testing on blood samples from kids and young people (up to 20 years) to create normal reference values.

Quick facts

Study typeObservational
AgesAny age to 20 Years
SexAll
Enrollment1500 (estimated)
SponsorAssistance Publique - Hôpitaux de Paris
Academic / other
Locations1 site (Paris, Paris)
StatusRecruiting
StartedJanuary 2, 2025
Main results expectedDecember 2026
Study endsDecember 2026
Registry record updatedAugust 26, 2025
Trial IDNCT06694415 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Kids and young people aged 20 years or younger who are undergoing a routine blood draw, are clinically well without known or suspected endocrine disease, and have no acute infection or inflammatory disorder are ideal candidates.

Probably not a fit

Patients with known or suspected endocrine disorders, or those with acute infectious or inflammatory conditions, are excluded and will not benefit from this reference-value collection.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, multicenter, non-randomized observational project using children and young people considered healthy to establish reference hormone values by LC‑MS/MS. An extra small blood tube (within safe volume limits) will be collected during routine clinic blood draws at participating AP‑HP pediatric endocrinology centers. Samples will be pseudonymized and entered into a secure REDCap database, and mass spectrometry analyses will be performed within the AP‑HP network under expert supervision. The resulting data will be used to produce pediatric reference ranges to support clinical interpretation when switching from immunoassays to LC‑MS/MS.

Why it matters

Potential benefit: If successful, clinicians will have more accurate and specific pediatric hormone reference ranges that can improve diagnosis and treatment decisions while reducing reliance on less-specific immunoassays.

How similar studies have gone: LC‑MS/MS is widely adopted and prior work has successfully produced adult and some pediatric reference data, though comprehensive multicenter pediatric norms remain limited.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Male or female patient ≤ 20 years old
* undergoing a blood sample as part of their pathology routine follow-up

Exclusion Criteria:

* Any identified or suspected endocrine pathology
* Any acute infectious or inflammatory disorder

Where it's running

  • Service d'Endocrinologie Pédiatrique-Explorations Fonctionnelles Hôpital Trousseau
    Paris, Paris, France
    Recruiting

Study contacts

  • Principal investigator: Eloïse Giabicani, MD, PhD — Organizational Affiliation: Assistance Publique - Hôpitaux de Paris (AP-HP en général)
  • Study coordinator: Eloïse Giabicani, MD, PhD
  • Email: eloise.giabicani@aphp.fr
  • Phone: +33 (0)1 49 28 66 94

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.