Non-surgical treatment for gum disease using chitosan and enamel matrix

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the effectiveness of a chitosan brush combined with an enamel matrix derivative for the non-surgical treatment of furcation defects in patients with stage III or IV periodontitis. Participants will be randomly assigned to receive either the experimental treatment or a control intervention after receiving detailed oral hygiene instructions. The study will focus on patients with specific types of furcation defects in their molars, ensuring a targeted approach to treatment. The trial will be conducted at the Riga Stradiņš University Institute of Stomatology in Latvia.

Why it matters

Who can join: the full rules

Inclusion criteria:

1. The patient is 18 years of age or older
2. The patient does not have any systemic diseases that may affect the results of the study
3. The patient has a plaque index of 20% or less at the study entry
4. The patient has a history of severe localized or generalized periodontitis (stage III or IV)
5. Completed the first and second steps of periodontal treatment (According to Treatment of stage I-III periodontitis-The EFP S3 level clinical practice guideline) (Sanz M. et al.)
6. Buccal and/or lingual Class 2A and/or 2B furcation involvement (FI) defects on both sides of the Mandibular first and/or second molars after completing the first and second steps of periodontal treatment.
7. Buccal Class 2A and/or 2B furcation involvement (FI) defects on both sides of the maxillary first and/or second molars after completion of the first and second step of periodontal treatment if furcation involvement on the palatal side (mesiopalatal and distopalatal) does not exceed Class 1.
8. Psychological appropriateness
9. Consents to all follow-up visits

Exclusion Criteria:

1. Patients who have systemic diseases that may affect the results of the study
2. Use of medications that may affect study results (anti-osteoporotic drugs, statins, corticosteroids, anticoagulants)
3. Patients who use calcium channel blockers, cyclosporine A or antiepileptic drugs if there are clinically visible hyperplastic changes in the gingival margin.
4. Patients who have received any type of systemic antibiotics in the last six months prior to the start of the study and patients starting antibiotics during the study
5. Patients requiring antibiotic premedication prior to periodontal treatment
6. Oncological disease
7. Chemotherapy and/or radiotherapy (active or history)
8. Pregnancy and breastfeeding
9. Any condition or current treatment which, in the opinion of the investigator and/or consulting physician, may present an unreasonable risk
10. Psychoemotional disorders and depression
11. Use of antipsychotic medication or antidepressants
12. Lack of patient motivation to undertake adequate dental care at home or complete periodontal treatment, patients residing outside Latvia
13. Molars with combined endodontic-periodontal lesions, active endodontic infection
14. Prosthetic factors for molars not allowing clinical measurements
15. Huge restoration or amalgam fillings that could potentially cause fractures or furcation involvement
16. Enamel pearls or filling or crown margins
17. Decay or root resorption
18. Tooth mobility degree 3
19. Molars in which the gingival margin is positioned apically from the entrance into the furcation area
20. Clinical attachment level and or pockets mesial and distal to the furcation involvement defect of 6 or more mm
21. Strong vomiting reflex that would prevent adequate periodontal treatment
22. People close to the study subjects, work colleagues, relatives, etc.

Where it's running

• Riga Stradins University Institute of Stomatology
  Riga, Latvia Recruiting

Study contacts

• Study coordinator: Anete Vaškevica, DDS
• Email: anete.vaskevica@rsu.lv
• Phone: +37120202028

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Mandibular molar furcation defects in advanced periodontitis: a regenerative treatment comparison

  In people with advanced gum disease, this study tests two regenerative treatments for Hamp Class II furcation defects in lower molars to see which works better and whether CBCT imaging matches what clinicians find during surgery.

  Recruiting University of Medicine and Pharmacy at Ho Chi Minh City · Ho Chi Minh City · NCT07770256

• A-PRF+ with Xenograft vs Collagen Membrane with Xenograft for Degree II Furcation Defects in Mandibular Molars

  This trial tests whether using advanced platelet-rich fibrin with a xenograft works better than a collagen membrane with a xenograft to treat degree II furcation defects in lower first molars of adults with periodontitis.

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• HbA1c screening in dental care to guide primary care referral for adults with advanced periodontitis

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• Masticatory Performance in Adults with Periodontitis

  This study tests whether chewing performance correlates with how severe periodontitis is in adults who have the condition.

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• Probiotics with or without vitamin B12 added to non-surgical treatment for advanced periodontitis

  This study will see if taking a probiotic lozenge alone or together with vitamin B12 during non-surgical periodontal treatment changes the oral microbiome and helps adults with Stage III or IV periodontitis.

  Recruiting University Hospital Heidelberg · Heidelberg, Baden-Wurttemberg · NCT07443410

• 3-month liquid platelet-rich fibrin treatment used during deep cleaning for stage II–IV periodontitis

  This 3-month test will see if flushing diseased gum pockets with your own liquid platelet-rich fibrin after deep cleaning helps healing for people with stage II–IV periodontitis.

  Recruiting Phase 2 Mahsa University · Jenjarum, Selangor · NCT07293962

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.