Non-invasive treatment for piriformis muscle pain
Official title: Strain-Counterstrain Treatment of Piriformis Pain
Run by Loma Linda University · NCT05023005 · Data updated 2026-11-12
This study is testing a new non-invasive treatment for people with piriformis muscle pain to see if it helps reduce their pain compared to a sham treatment.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Loma Linda University Academic / other |
| Locations | 1 site (Loma Linda, California) |
| Status | Recruiting |
| Started | September 2026 |
| Main results expected | September 2027 |
| Study ends | September 2027 |
| Registry record updated | April 24, 2026 |
| Trial ID | NCT05023005 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 to 65 with a tender point in the piriformis muscle.
✕Probably not a fit
Patients with significant hip mobility limitations, active cancer, or those receiving concurrent treatments may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to evaluate the effectiveness of strain-counterstrain treatment specifically targeting the piriformis muscle in patients experiencing pain. Participants will be divided into two groups: one receiving the actual treatment and the other receiving a sham treatment focused on the hamstring muscle. Pain levels will be assessed using the Oswestry Disability Index Questionnaire and the Visual Analog Scale before and after each of the two treatment sessions, which are spaced 1-2 weeks apart. An algometer will also be utilized to measure changes in pain pressure threshold pre and post-treatment.
Why it matters
Potential benefit: If successful, this treatment could provide a non-invasive option for patients suffering from piriformis-related pain.
How similar studies have gone: While the specific approach of strain-counterstrain for piriformis pain is less common, similar non-invasive treatments have shown promise in managing musculoskeletal pain.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 to 65 years of age * Tender point (or trigger point) in piriformis muscle determined by physical exam Exclusion criteria: * Less than 45 degrees of active hip flexion, less than 5 degrees of active hip internal rotation or less than 30 degrees of active hip external rotation, on side of affected piriformis * Unable to lay prone * Non-English speaker * Inability to attend 2 sessions within the same month * Active cancer * Pregnant * Diagnosis of lumbar radiculopathy * Greater than grade 1 lumbar spondylolisthesis * Presence of lumbar region Pars Defect * Receiving massage, acupuncture, chiropractic treatments, osteopathic treatments during study period.
Where it's running
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Loma Linda University Health
Loma Linda, California, United States Recruiting
Study contacts
- Principal investigator: Mickey Lui — Loma Linda University Health
- Study coordinator: Roya Vahdatinia, DO
- Email: rvahdatinia@llu.edu
- Phone: 9095586202
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Interfascial hydrodissection added to ultrasound-guided piriformis injection for piriformis syndrome
In adults with piriformis syndrome, this study tests whether adding interfascial hydrodissection to a targeted piriformis injection helps reduce pain and improve function.
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Post-Isometric Relaxation vs Reciprocal Inhibition for Piriformis Syndrome
A controlled trial tests two manual therapy techniques to see which helps people with piriformis syndrome more when used with standard physiotherapy.
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Post-isometric relaxation versus active isolated stretching for piriformis syndrome
We are testing whether post-isometric relaxation or active isolated stretching better reduces pain and improves movement in adults aged 20–55 with piriformis syndrome.
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Lumbar stabilization exercises versus muscular chain therapy for mechanical chronic low back pain
This trial tests whether lumbar stabilization exercises or muscular chain (posterior sagittal) therapy better reduce pain and disability in people aged 18–30 with mechanical chronic low back pain.
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Post-Isometric Relaxation and Myofascial Release for Low Back Pain with Lower Cross Syndrome
This trial tests whether combining post-isometric relaxation with myofascial release helps reduce pain and improve flexibility and function for adults with low back pain and lower cross syndrome.
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Comparing instrument-assisted soft tissue mobilization versus PNF stretching for athletes with piriformis syndrome.
This will test whether instrument-assisted soft tissue mobilization or PNF stretching better reduces pain and improves hip motion in athletes aged 18–35 with piriformis syndrome.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.