Non-invasive therapies to improve arm and hand function in spinal cord injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates two non-invasive therapies aimed at restoring arm and hand function in individuals with chronic cervical spinal cord injury. Participants will undergo a crossover design, receiving transcutaneous spinal cord stimulation and paired corticospinal-motoneuronal stimulation, each combined with rehabilitation, for two months with a one-month washout period in between. The study will assess safety, effectiveness, and patient-reported outcomes related to daily living and quality of life, alongside neurophysiological changes. The goal is to tailor treatments to individual needs, enhancing personalized care and outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Cervical (C2-C8) level SCI
* \> 9 months post-injury
* Traumatic SCI
* AIS A-D
* Stable dose of anti-spasmodics

Exclusion Criteria:

* individuals with injury to the nervous system other than to the spinal cord
* pregnant

Where it's running

• Glenrose Rehabilitation Hospital
  Edmonton, Alberta, Canada Recruiting

Study contacts

• Principal investigator: Jessica M D'Amico, PhD — University of Alberta
• Study coordinator: Jessica M D'Amico, PhD
• Email: damico1@ualberta.ca
• Phone: 7802039478

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Electrical stimulation for arm function after cervical spinal cord injury in veterans

  In veterans with a recent cervical spinal cord injury, researchers are testing whether transcutaneous spinal stimulation (TSS) can improve arm and hand function more than the standard functional electrical stimulation (FES) during inpatient rehab.

  Recruiting Center for Veterans Research and Education · Minneapolis, Minnesota · NCT07911657

• Wireless implant for brain-computer interface in people with tetraplegia from spinal cord injury

  This trial tests a wireless brain-computer interface implanted in adults with tetraplegia to see if it is safe and if it can help restore some function.

  Recruiting BCIFlex Medical Technology Co., Ltd. · Beijing · NCT07784088

• Epidural spinal cord stimulation to help breathing after cervical spinal cord injury

  This trial tests whether adding epidural spinal cord stimulation to standard care can improve breathing in adults with cervical spinal cord injury and respiratory failure.

  Recruiting at 2 sites Zhongda Hospital · Nanjing, Jiangsu and 1 other locations · NCT07722130

• Optimizing sensory feedback to maximize hand and arm function after tetraplegia

  This project tests different patterns of brain and nerve electrical stimulation to restore touch and pressure sensations in people with cervical spinal cord injuries who already have ReHAB implants.

  Recruiting Case Western Reserve University · Cleveland, Ohio · NCT07225582

• Non-invasive breathing therapies to improve respiratory function after chronic spinal cord injury

  We will try combining non-invasive spinal electrical stimulation and brief high-carbon-dioxide breathing with respiratory resistance exercises to see if they improve breathing in adults with chronic incomplete spinal cord injury.

  Recruiting Thomas Jefferson University · Philadelphia, Pennsylvania · NCT07135583

• Using brain-computer interface technology to improve walking in spinal cord injury patients

  This study is testing a new brain-computer interface system to see if it can help people with spinal cord injuries walk better and improve their quality of life.

  Recruiting Xuanwu Hospital, Beijing · Beijing, Beijing Municipality · NCT06939660

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.