Non-invasive method to differentiate types of fast heart rhythms
Non-invasive Differentiation of Supraventricular Tachyarrhythmias by Questionnaire and High-resolution ECG in the Context of Ablation Treatment
This study is testing a new way to tell different types of fast heart rhythms apart, like atrial fibrillation, by using patient surveys and special heart tests for people who are about to have treatment for these conditions.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1250 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | RWTH Aachen University Academic / other |
| Locations | 1 site (Aachen, North Rhine-Westphalia) |
| Trial ID | NCT06061120 on ClinicalTrials.gov |
What this trial studies
This study aims to differentiate between various types of supraventricular tachyarrhythmias, including atrial fibrillation, using a combination of patient questionnaires and advanced signal-averaged electrocardiograms (ECGs). Patients scheduled for ablation of these arrhythmias will complete structured questionnaires to identify triggers and symptoms associated with their condition. Additionally, high-resolution ECGs will be recorded to analyze P-wave characteristics and create a virtual atrial ECG for better diagnosis. The goal is to improve the understanding and management of these heart rhythm disorders.
Who should consider this trial
Good fit: Ideal candidates are patients scheduled for ablation of supraventricular tachycardia, including those with atrial fibrillation and AV nodal reentry tachycardia.
Not a fit: Patients with unstable conditions requiring intensive medical care or those with significant cognitive limitations may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to more accurate diagnoses and tailored treatments for patients with supraventricular tachyarrhythmias.
How similar studies have performed: While the approach of using questionnaires and advanced ECGs is promising, it is relatively novel and has not been extensively tested in previous studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Scheduled for ablation of a supraventricular tachycardia (atrial fibrillation, typical atrial flutter, AV nodal reentry tachycardia, accessory pathway) * majority Exclusion Criteria: * Unstable patient with need for intensive medical care * Lack of language skills or limited cognitive abilities that prevent a differentiated anamnesis and information. Exclusion criteria for study section Questionnaire: \- Competing clinically present arrhythmias, including relevant supra- and ventricular extrasystole (\>5%/die). Exclusion criteria for study section Extended high-resolution ECG: * Previous electrophysiological ablation at the same site for atrial fibrillation. * Relevant supra- and ventricular extrasystole (\>5%/die). * Other clinically present arrhythmias are not excluded if they can be sequentially triggered and ablated (e.g. atrial fibrillation and atrial flutter). Since separate detection is possible with the high-resolution ECG. * Implanted active electrical device (e.g. pacemaker, defibrillator, deep brain pacemaker) * Allergy to measuring electrodes
Where this trial is running
Aachen, North Rhine-Westphalia
- RWTH Aachen University — Aachen, North Rhine-Westphalia, Germany (Recruiting)
Study contacts
- Principal investigator: Matthias D Zink, MD — RWTH Aachen University
- Study coordinator: Matthias D Zink, MD
- Email: mzink@ukaachen.de
- Phone: 00492418035113
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.