Non-invasive intracranial pressure estimation using periorbital vein occlusion pressure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The procedure uses a pneumatic mask and ultrasound to isolate and measure the occlusion pressure of the periorbital vein, aiming to derive a non-invasive estimate of intracranial pressure. Measurements are performed in hospitalized adults who already have an invasive ICP monitor so the new method can be directly compared to gold-standard readings. Patients with facial or skull trauma, recent cranial surgery, orbital venous disease, or active bleeding are excluded to avoid interference with measurements. The trial is conducted at Baylor College of Medicine and uses concurrent invasive ICP readings as the reference standard.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male or female
* Age \> 18
* Equipped with an invasive ICP monitor as part of standard of care

Exclusion Criteria:

* Presence of facial and/or skull trauma that could hinder placement of the pneumatic mask or contraindicate ultrasound on the forehead
* History of recent cranial surgery or hemicraniectomy
* Active bleeding (proven or suspected)
* History or known pathological condition or injury linked to the orbital socket influencingvenous outflow (e.g. Grave disease, tumor, inflammation, trauma, glaucoma, etc.)
* History, or known vein stenosis in ophthalmic veins/cavernous sinus
* Any other condition that would interfere with measurement technique and routine clinical care according to the judgment of the investigator.

Where it's running

• Baylor College of Medicine
  Houston, Texas, United States Recruiting

Study contacts

• Study coordinator: Damon Judges
• Email: d.judges@compremium.ch
• Phone: +41775071995

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.