Non-invasive diagnosis of coronary microvascular disease
Non-invasive Diagnosis of Coronary Microvascular Disease Using Novel CMR and CT Techniques: a Pilot Study
This study is testing new non-invasive ways to diagnose coronary microvascular disease in patients with stable chest pain who don't have major artery blockages.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 20 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Leicester Academic / other |
| Locations | 1 site (Leicester, Leicestershire) |
| Trial ID | NCT06070662 on ClinicalTrials.gov |
What this trial studies
This study aims to explore non-invasive methods for diagnosing coronary microvascular disease (CMD) in patients experiencing stable chest pain without significant blockage in major heart arteries. It focuses on patients who have undergone coronary angiography and aims to gather initial data on the effectiveness of cardiac magnetic resonance scans and other non-invasive tests in identifying CMD. By improving diagnostic techniques, the study seeks to enhance treatment options for patients suffering from microvascular angina. The research is observational and will analyze existing data from participants of a related study.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older who are currently participating in the 'CMR versus CT-FFR in CAD' study and are referred for invasive coronary angiography due to chest pain.
Not a fit: Patients with recent acute coronary syndrome, severe claustrophobia, or contraindications to cardiac magnetic resonance imaging will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic methods for coronary microvascular disease, resulting in better treatment options for patients with microvascular angina.
How similar studies have performed: While invasive methods for diagnosing CMD have been established, this study's focus on non-invasive techniques represents a novel approach that has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Current participant of the 'CMR versus CT-FFR in CAD' study * Continue to meet the inclusion criteria for the main study: * Patients aged ≥18 years * Referred for invasive coronary angiography for investigation of chest pain * Willing and able to give informed consent * Willing and able (in the Investigators opinion) to comply with all study requirements. * Willing to allow his or her General Practitioner and consultant, if appropriate, to be notified of participation in the study. * Able to understand written English * Able to perform exercise in the MRI scanner Study arm: * No evidence of obstructive or non-obstructive CAD on research CTCA * Myocardial perfusion defect detected on adenosine stress CMR indicative of CMD Control arm: • Evidence of multivessel CAD on research CTCA Exclusion Criteria: * Meet the exclusion criteria for the main study: * Recent acute coronary syndrome (\< 6 months) * Severe claustrophobia * Absolute contraindications to CMR - those with MR conditional or safe devices will be included * Second-/third-degree atrioventricular block * Severe chronic obstructive pulmonary disease * Moderate-severe asthma * Estimated glomerular filtration rate \<30 ml/min/1.73m2 * Women who are pregnant, breast-feeding or of child-bearing potential (premenopausal women) * Contraindication to iodinated contrast * Participants who have participated in a research study involving an investigational product in the past 12 weeks * Patients unable to understand written English
Where this trial is running
Leicester, Leicestershire
- Glenfield Hospital, University Hospitals of Leicester — Leicester, Leicestershire, United Kingdom (Recruiting)
Study contacts
- Principal investigator: Ranjit Arnold — University of Leicester
- Study coordinator: Ranjit Arnold
- Email: jra14@leicester.ac.uk
- Phone: +44116 258 3038
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.