Non-invasive diagnosis of coronary microvascular disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to explore non-invasive methods for diagnosing coronary microvascular disease (CMD) in patients experiencing stable chest pain without significant blockage in major heart arteries. It focuses on patients who have undergone coronary angiography and aims to gather initial data on the effectiveness of cardiac magnetic resonance scans and other non-invasive tests in identifying CMD. By improving diagnostic techniques, the study seeks to enhance treatment options for patients suffering from microvascular angina. The research is observational and will analyze existing data from participants of a related study.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Current participant of the 'CMR versus CT-FFR in CAD' study
* Continue to meet the inclusion criteria for the main study:
* Patients aged ≥18 years
* Referred for invasive coronary angiography for investigation of chest pain
* Willing and able to give informed consent
* Willing and able (in the Investigators opinion) to comply with all study requirements.
* Willing to allow his or her General Practitioner and consultant, if appropriate, to be notified of participation in the study.
* Able to understand written English
* Able to perform exercise in the MRI scanner

Study arm:

* No evidence of obstructive or non-obstructive CAD on research CTCA
* Myocardial perfusion defect detected on adenosine stress CMR indicative of CMD

Control arm:

• Evidence of multivessel CAD on research CTCA

Exclusion Criteria:

* Meet the exclusion criteria for the main study:
* Recent acute coronary syndrome (\< 6 months)
* Severe claustrophobia
* Absolute contraindications to CMR - those with MR conditional or safe devices will be included
* Second-/third-degree atrioventricular block
* Severe chronic obstructive pulmonary disease
* Moderate-severe asthma
* Estimated glomerular filtration rate \<30 ml/min/1.73m2
* Women who are pregnant, breast-feeding or of child-bearing potential (premenopausal women)
* Contraindication to iodinated contrast
* Participants who have participated in a research study involving an investigational product in the past 12 weeks
* Patients unable to understand written English

Where it's running

• Glenfield Hospital, University Hospitals of Leicester
  Leicester, Leicestershire, United Kingdom Recruiting

Study contacts

• Principal investigator: Ranjit Arnold — University of Leicester
• Study coordinator: Ranjit Arnold
• Email: jra14@leicester.ac.uk
• Phone: +44116 258 3038

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Comprehensive coronary physiology testing for adults with angina but no blocked coronary arteries in the Czech Republic

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• Measuring retinal blood vessel density in patients with microvascular angina

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• Personalized exercise and dietary program for patients with microvascular coronary dysfunction

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• Evaluating coronary microvascular dysfunction in heart failure patients

  This study is trying to see if problems with tiny blood vessels in the heart affect how well people with heart failure can improve their heart function after treatment.

  Recruiting Samsung Medical Center · Seoul · NCT06243653

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.