Non-invasive brain stimulation to enhance memory in Alzheimer's patients
Testing High Definition Transcranial Direct Current Stimulation (HD-tDCS) as Treatment of Mild Cognitive Impairment
NA · University of Michigan · NCT03875326
This study is testing whether different levels of non-invasive brain stimulation can help improve memory in people with mild cognitive impairment and Alzheimer's disease.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 240 (estimated) |
| Ages | 55 Years and up |
| Sex | All |
| Sponsor | University of Michigan (other) |
| Locations | 1 site (Ann Arbor, Michigan) |
| Trial ID | NCT03875326 on ClinicalTrials.gov |
What this trial studies
This research investigates the effects of varying doses of non-invasive brain stimulation on individuals with mild cognitive impairment (MCI) and dementia of the Alzheimer's type (DAT). The study aims to determine the optimal level of stimulation needed to improve memory and cognitive functions, while also assessing changes in brain activity through advanced imaging techniques like fMRI and PET scans. Participants will undergo cognitive tests and questionnaires to evaluate any improvements in their memory and related abilities. The findings could inform future treatment strategies for Alzheimer's disease.
Who should consider this trial
Good fit: Ideal candidates include individuals diagnosed with mild cognitive impairment or dementia of the Alzheimer's type who meet specific MRI compatibility criteria.
Not a fit: Patients with certain neurological or psychiatric conditions, or severe sensory impairments may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved memory and cognitive function in patients with mild cognitive impairment and Alzheimer's disease.
How similar studies have performed: Other studies have shown promise with non-invasive brain stimulation techniques, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Diagnosis of Mild Cognitive Impairment (MCI) or dementia of the Alzheimer's type (DAT) 2. Must be MRI compatible, criteria that also apply for High Definition transcranial direct current stimulation (HD-tDCS; e.g., absence of metallic or electronic implants in the upper body or head) 3. Stable on relevant medications for at least 4 weeks prior to study enrollment Exclusion Criteria: 1. Certain neurological diseases 2. Certain psychiatric conditions 3. Severe sensory impairment
Where this trial is running
Ann Arbor, Michigan
- University of Michigan — Ann Arbor, Michigan, United States (RECRUITING)
Study contacts
- Principal investigator: Benjamin Hampstead, PhD — Associate Professor
- Study coordinator: Stephen M Schlaefflin, BS
- Email: schlst@med.umich.edu
- Phone: 734-936-7360
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Mild Cognitive Impairment, Dementia of Alzheimer Type, Dementia, Memory, Cognitive Rehabilitation, PET scan, fMRI, Brain Stimulation