Non-invasive brain stimulation techniques for neurological rehabilitation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of a novel non-invasive brain stimulation protocol called 'mirror-PAS' in promoting motor recovery and reducing pain in patients with neurological conditions such as stroke and phantom limb pain. Participants will undergo two separate sessions of paired associative stimulation (PAS), one using standard methods and the other using the innovative mirror-PAS approach. The study aims to compare the neurophysiological and behavioral outcomes of both protocols to determine which is more effective in enhancing brain plasticity and sensory-motor function.

Why it matters

Who can join: the full rules

Inclusion criteria for stroke patients:

* age from 18 to 85 years
* single, unilateral, hemispheric stroke (cortical or sub-cortical areas)
* stroke confirmed by neuroimaging (CT or MRI)
* stroke at least 4 months before enrollment
* hemiparesis of the upper limb resulting from stroke or hemianesthesia clinically documented

Exclusion criteria for stroke patients:

* contraindications to TMS (Rossi et all, 2021)
* other neurological conditions (e.g., Parkinson's Disease, Multiple Sclerosis, ALS)
* other orthopedic condition that affected the hand (e.g., carpal tunnel syndrome)

Inclusion criteria for PLP patients:

* age from 18 to 90 years
* amputation of one part of the upper limb at least 2 months before enrollment
* presence of stable phantom limb pain at least 2 months prior to enrollment

Exclusion criteria for PLP patients:

* contraindications to TMS (Rossi et all, 2021)
* other neurological, orthopedical or psychiatric conditions

Where it's running

• Istituto Auxologico Italiano IRCCS
  Milan, Lombardy, Italy Recruiting

Study contacts

• Principal investigator: Nadia Bolognini, PhD — Laboratorio di Neuropsicologia, IRCCS Istituto Auxologico Italiano
• Study coordinator: Nadia Bolognini, PhD
• Email: n.bolognini@auxologico.it
• Phone: +390261911

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Quadriceps muscle activity and gait in people after stroke with stiff-knee gait vs healthy controls

  We will test whether quadriceps muscle activity and walking movement differ between adults with post-stroke stiff-knee gait and healthy adults.

  Recruiting Centre National de Rééducation Fonctionnelle et de Réadaptation · Luxembourg, Luxembourg · NCT07857967

• Home-based vs. in-clinic upper extremity rehabilitation after stroke

  This study tests whether a 20-hour home telerehabilitation program (tele-CPASS) works as well as the same in-clinic CPASS therapy for improving arm and hand function after stroke.

  Recruiting at 3 sites University of Texas, El Paso · El Paso, Texas and 2 other locations · NCT07661849

• Repetitive transcranial magnetic stimulation to improve heart-autonomic function after stroke

  This test adds rTMS to usual neurological rehabilitation to see if it improves heart rate variability, autonomic symptoms, arm strength, and quality of life in people at least three months after a stroke.

  Recruiting Afyonkarahisar Health Sciences University · Afyonkarahisar · NCT07482501

• Spatial StimelMD for upper-limb recovery after stroke or traumatic brain injury

  This trial will test whether adding the Spatial StimelMD device to standard rehabilitation helps adults with upper-limb weakness after stroke or traumatic brain injury improve arm movement.

  Recruiting Motion Informatics LTD · Haifa · NCT07404761

• Deep phenotyping to explore recovery in young adults after stroke

  This project will test whether a detailed health and sample-collection approach (deep phenotyping) is practical and acceptable for people aged 18–55 who have had a stroke.

  Recruiting The Florey Institute of Neuroscience and Mental Health · Heidelberg, Victoria and 1 other locations · NCT07019493

• Wrist-worn device to encourage use of the weaker arm after a recent stroke

  This trial tests whether a wrist-worn sensor system plus motor and behavioral home coaching helps people 1–6 months after a stroke with moderate arm weakness use their affected arm more than a usual home-exercise program.

  Recruiting Spaulding Rehabilitation Hospital · Boston, Massachusetts · NCT06797154

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.