Non-invasive brain stimulation for treating convergence insufficiency

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the effectiveness of non-invasive brain stimulation in adults with symptomatic convergence insufficiency. Participants will be randomized into three groups: one receiving non-invasive brain stimulation, another undergoing office-based vergence/accommodative therapy, and a third receiving sham stimulation. The study seeks to determine if non-invasive brain stimulation can reduce the treatment duration from 12 weeks to 8 weeks and if it is as effective as traditional therapy in alleviating symptoms. The trial will measure improvements in visual function and symptom relief.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Best-corrected visual acuity of \> 20/25 in each eye at distance and near
* Exophoria at near at least 4∆ greater than at far
* Receded near point of convergence of \> 6 cm break
* Insufficient positive fusional vergence at near (\< 15∆ base-out blur or break)
* CISS score of 16 and greater for children or 21 and greater for adults
* Have had a dilated fundus examination within the last 12 months
* Informed consent and willingness to participate in the study and be randomized

Exclusion Criteria:

* Previously treated for convergence insufficiency with home- or office-based vergence/accommodative therapy
* Amblyopia (\> 2-line difference in best-corrected visual acuity between the two eyes)
* Constant strabismus
* History of strabismus surgery
* Convergence insufficiency secondary to acquired brain injury or neurological disorder
* Manifest or latent nystagmus
* Systemic disease known to affect accommodation, vergence, and ocular motility including multiple sclerosis, Graves disease, myasthenia gravis, Parkinson's disease, cerebral palsy, and diabetes
* Developmental disability, attention deficit hyperactivity disorder (ADHD), learning disability or cognitive dysfunction that would interfere with treatment
* Taking medications that can affect normal neurological function including antipsychotics, antiepileptics, and opioids
* Presence of metal or electronic implants in or on the body, including pacemakers

Where it's running

• Midwestern University Eye Institute
  Downers Grove, Illinois, United States Recruiting

Study contacts

• Study coordinator: Arijit Chakraborty, PhD
• Email: achakr@midwestern.edu
• Phone: 630-960-3172

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.