Non-invasive blood glucose measurement using Raman spectroscopy on the fingernail

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational project collects Raman spectra from participants' nails to derive blood glucose estimates without finger pricks. Adults aged 18–75, including people with diagnosed diabetes and healthy volunteers, will be scanned at Beijing Shijitan Hospital and provide standard capillary or venous glucose measurements for comparison. Participants with nail disease, recent use of nail products, pregnancy, severe chronic illness, or inability to complete procedures will be excluded to avoid confounding the optical measurements. The study compares Raman-derived glucose values with conventional measurements to characterize accuracy and clinical feasibility.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Age range: 18-75 years old. Gender: unlimited. Health status: patients with diagnosed diabetes or healthy volunteers. Nail health status: no obvious infection, discoloration, peeling and other lesions of the nail, so as to ensure the accuracy of Raman spectroscopy measurement.

Willing to participate in the study and sign the informed consent.

Exclusion Criteria:

Nail diseases: such as fungal infections, psoriasis, trauma resulting in nail damage or deformity.

The presence of factors that influenced the measurement results: Participants who used nail polish, fake nails, or nail products. Recent use of drugs containing heavy metals (which may affect nail composition) and skin conditions are not appropriate for such tests.

Pregnant or lactating women. People with serious chronic diseases (such as terminal cancer, end-stage renal disease) or mental illness.

Non-cooperation or inability to complete the entire research process, such as refusal or inability to complete Raman spectrum acquisition.

Where it's running

• Beijing Shijitan Hospital
  Beijing, Beijing Municipality, China Recruiting
• Beijing Shijitan Hospital
  Haidian, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Yuanyuan Miao
• Email: miaoyuanyuan1001@163.com
• Phone: +86 18815015576

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.