Clinical trial Recruiting at 1 site Interventional Ages 18 to 30

NMES combined with PNF for ankle sprain rehab

Official title: Effects of Neuromuscular Electrical Stimulation Combined With Proprioceptive Neuromuscular Facilitation in Adults With a History of Ankle Sprain

Run by Fooyin University · NCT07190599 · Data updated 2026-11-12

This program will test whether adding electrical muscle stimulation (NMES) to PNF stretching helps 18–30-year-olds with past ankle sprains reduce pain and improve balance, strength, and movement.

Quick facts

Study typeInterventional
Ages18 Years to 30 Years
SexAll
Enrollment60 (estimated)
SponsorFooyin University
Academic / other
Locations1 site (Kaohsiung City, No. 151, Jinxue Road, Daliao District)
StatusRecruiting
StartedOctober 1, 2025
Main results expectedMarch 31, 2026
Study endsJuly 31, 2026
Registry record updatedNovember 17, 2025
Trial IDNCT07190599 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 18–30 with a prior ankle sprain who do not have fractures, dislocations, grade III sprains, significant swelling, bony restrictions, neuropathy, or other neuromuscular disorders.

Probably not a fit

Patients with recent fractures, dislocations, grade III sprains, active swelling, bony mechanical restrictions, neuropathy, or other neuromuscular conditions are unlikely to be eligible or benefit from this protocol.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional trial will enroll 60 adults aged 18–30 with a history of ankle sprain and randomize them into two groups of 30. The experimental group will receive PNF stretching combined with neuromuscular electrical stimulation (NMES) while the control group will receive PNF stretching alone, with both groups training three times per week for four weeks (12 sessions total). Outcomes measured before and after the program include pain, balance, range of motion, proprioception, strength, joint mobility, and functional limitations. Participants with fractures, dislocations, grade III sprains, bony restrictions, swelling, neuropathy, or other neuromuscular disorders are excluded.

Why it matters

Potential benefit: If successful, combining NMES with PNF could reduce pain and improve balance, strength, and functional ability more than PNF alone for young adults with chronic ankle problems.

How similar studies have gone: Separate studies support NMES for strengthening and PNF for flexibility and proprioception, but direct evidence for the combined NMES+PNF approach in ankle sprain rehab is limited.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Aged 18-30 years
* Adults with a history of ankle sprain

Exclusion Criteria:

* Participants with ankle fractures, dislocations, grade III ankle sprains, bony restrictions, swelling, neuropathy, or any other neuromuscular disorders are excluded.

Where it's running

  • Fooyin University
    Kaohsiung City, No. 151, Jinxue Road, Daliao District, Taiwan
    Recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.