Next-generation treatments for Alzheimer's disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study explores innovative approaches to treating Alzheimer's disease (AD) by focusing on the mechanisms of synaptic plasticity, which are crucial for learning and memory. Given the failures of previous trials targeting amyloid and tau proteins, this research aims to develop genetically encoded engineered proteins that may enhance neuronal connections. The study seeks to address the heterogeneous nature of AD by intervening at a cellular level to potentially improve cognitive function. Participants will be closely monitored to assess the efficacy of these new therapeutic strategies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Manifest clinical criteria for probable AD;
* Age between 18 and 80 years;
* Signed informed consent obtained;

Exclusion Criteria:

* Patients suffering from other neurological diseases;
* Patients with coagulation disorders or in treatment with anticoagulant drugs;
* Patients suffering from dermatological diseases and connective tissue diseases;
* Patients suffering from other organic, psychiatric diseases or laboratory abnormalities could preclude participation or invalidate the study results;
* Inability to give informed consent.

Where it's running

• Fondazione Policlinico Universitario A. Gemelli IRCCS
  Roma, Italy Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.