Clinical trial Recruiting at 3 sites Observational Ages Any age to 18

New treatment recommendations for children with Acute Lymphoblastic Leukemia

Official title: Recommendations for the Treatment of Children With Acute Lymphoblastic Leukemia in the GFAOP

Run by French Africa Pediatric Oncology Group · NCT04794296 · Data updated 2026-11-12

This study is testing new treatment guidelines for children with Acute Lymphoblastic Leukemia to see if they can help more kids go into remission and stay cancer-free.

Quick facts

Study typeObservational
AgesAny age to 18 Years
SexAll
Enrollment500 (estimated)
SponsorFrench Africa Pediatric Oncology Group
Academic / other
Drugs / interventionschemotherapy, Methotrexate
Locations3 sites (Abidjan and 2 other locations)
StatusRecruiting
StartedNovember 15, 2021
Main results expectedDecember 31, 2028
Study endsDecember 31, 2030
Registry record updatedMarch 2, 2026
Trial IDNCT04794296 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are children aged 0 to 18 years who are newly diagnosed with ALL and have not received prior chemotherapy.

Probably not a fit

Patients with ALL L3 (Burkitt), those previously treated with chemotherapy, or those with Trisomy 21 may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the implementation of new treatment recommendations for children diagnosed with Acute Lymphoblastic Leukemia (ALL). It focuses on both standard and high-risk forms of ALL, introducing anthracycline induction and high-dose consolidation therapies. The study seeks to ensure the feasibility of these recommendations and aims for a complete remission rate of approximately 85% after induction treatment. Additionally, it will assess the long-term survival without relapse in patients achieving remission.

Why it matters

Potential benefit: If successful, this study could significantly improve treatment outcomes and survival rates for children with Acute Lymphoblastic Leukemia.

How similar studies have gone: Previous studies in developing countries have shown that tailored treatment protocols can significantly improve outcomes for children with ALL, suggesting potential success for this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

Children 0 to 18 ALL first diagnosis No prior chemotherapy Cytology FAB L1 or L2

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Exclusion Criteria:

ALL L3 (Burkitt) ALL previously treated with chemotherapy Trisomy 21

Where it's running

  • CHU de Treichville à ABIDJAN
    Abidjan, Côte d’Ivoire
    Recruiting
  • CHU Donka 030 BP 554
    Conakry, Guinea
    Recruiting
  • Hôpital Aristide Le Dantec, Avenue Pasteur,
    Dakar, Senegal
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.