New treatment recommendations for children with Acute Lymphoblastic Leukemia
Official title: Recommendations for the Treatment of Children With Acute Lymphoblastic Leukemia in the GFAOP
Run by French Africa Pediatric Oncology Group · NCT04794296 · Data updated 2026-11-12
This study is testing new treatment guidelines for children with Acute Lymphoblastic Leukemia to see if they can help more kids go into remission and stay cancer-free.
Quick facts
| Study type | Observational |
|---|---|
| Ages | Any age to 18 Years |
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | French Africa Pediatric Oncology Group Academic / other |
| Drugs / interventions | chemotherapy, Methotrexate |
| Locations | 3 sites (Abidjan and 2 other locations) |
| Status | Recruiting |
| Started | November 15, 2021 |
| Main results expected | December 31, 2028 |
| Study ends | December 31, 2030 |
| Registry record updated | March 2, 2026 |
| Trial ID | NCT04794296 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are children aged 0 to 18 years who are newly diagnosed with ALL and have not received prior chemotherapy.
✕Probably not a fit
Patients with ALL L3 (Burkitt), those previously treated with chemotherapy, or those with Trisomy 21 may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to evaluate the implementation of new treatment recommendations for children diagnosed with Acute Lymphoblastic Leukemia (ALL). It focuses on both standard and high-risk forms of ALL, introducing anthracycline induction and high-dose consolidation therapies. The study seeks to ensure the feasibility of these recommendations and aims for a complete remission rate of approximately 85% after induction treatment. Additionally, it will assess the long-term survival without relapse in patients achieving remission.
Why it matters
Potential benefit: If successful, this study could significantly improve treatment outcomes and survival rates for children with Acute Lymphoblastic Leukemia.
How similar studies have gone: Previous studies in developing countries have shown that tailored treatment protocols can significantly improve outcomes for children with ALL, suggesting potential success for this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Children 0 to 18 ALL first diagnosis No prior chemotherapy Cytology FAB L1 or L2 \- Exclusion Criteria: ALL L3 (Burkitt) ALL previously treated with chemotherapy Trisomy 21
Where it's running
-
CHU de Treichville à ABIDJAN
Abidjan, Côte d’Ivoire Recruiting -
CHU Donka 030 BP 554
Conakry, Guinea Recruiting -
Hôpital Aristide Le Dantec, Avenue Pasteur,
Dakar, Senegal Recruiting
Study contacts
- Study coordinator: Ndella Ms DIOUF, MD
- Email: ndella.diouf@gfaop.org
- Phone: 00(221)77 656 49 13.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.