New treatment approach for unexplained infertility
A Higher Ovulation and Pregnancy Rates in Patients With Unexplained Infertility After Application of ANTIUI Protocol: A Randomized Multicenter Controlled Study
This study is testing a new treatment plan to help people with unexplained infertility improve their chances of getting pregnant using medication and a common procedure called IUI.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 200 (estimated) |
| Ages | 20 Years to 35 Years |
| Sex | Female |
| Sponsor | Tanta University Academic / other |
| Locations | 1 site (Tanta, Gharbia) |
| Trial ID | NCT04754243 on ClinicalTrials.gov |
What this trial studies
This clinical trial evaluates a new protocol called ANTIUI aimed at improving ovulation and pregnancy rates in patients diagnosed with unexplained infertility. Participants will undergo treatment with gonadotropins and a standard intrauterine insemination (IUI) protocol. The study focuses on individuals who have normal hormonal and structural evaluations but have not achieved pregnancy after a reasonable duration of trying to conceive. The goal is to provide an alternative option before considering more invasive procedures like ICSI.
Who should consider this trial
Good fit: Ideal candidates are women under 35 years with unexplained infertility lasting less than 5 years and good ovarian reserve.
Not a fit: Patients over 35 years, those with a longer duration of infertility, or those with abnormal semen analysis will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could enhance the chances of conception for patients facing unexplained infertility.
How similar studies have performed: Other studies have shown promising results with similar protocols, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Unexplained infertility * Duration less than 5 years * Good ovarian reserve AMH\> 1.1 * Normal patent tubes * No previous trials of IUI with the same protocol Exclusion Criteria: * Age \> 35 years * Duration of infertility\> 5 years * Abnormal semen * Hypoplastic tubes * prior failed ICSI
Where this trial is running
Tanta, Gharbia
- Ayman Shehata Dawood — Tanta, Gharbia, Egypt (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.