New technology for managing fluid changes in prosthetic sockets for amputees

NIH Release/Relock Socket

Not applicable Interventional University of Washington · NCT04305782

This study is testing a new type of prosthetic socket for lower-limb amputees to see if it can better manage fluid changes and improve comfort and mobility.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment100 (estimated)
Ages18 Years and up
SexAll
SponsorUniversity of Washington Academic / other
Locations1 site (Seattle, Washington)
Trial IDNCT04305782 on ClinicalTrials.gov

What this trial studies

This research aims to develop and assess a novel prosthetic socket technology designed to manage fluid volume fluctuations in the residual limb of lower-limb amputees. The technology allows for partial doffing of the socket, which may help improve comfort and mobility by facilitating better fit and reducing skin injuries. Participants will engage in both in-lab and out-of-lab interventions to evaluate the effectiveness of this new approach. The study seeks to enhance understanding of how socket adjustments can aid in fluid recovery and retention.

Who should consider this trial

Good fit: Ideal candidates include individuals with a trans-tibial amputation who regularly use a prosthesis and can walk with it for at least 2 minutes.

Not a fit: Patients currently experiencing skin breakdown or those unable to meet the inclusion criteria may not benefit from this study.

Why it matters

Potential benefit: If successful, this technology could significantly improve the comfort and mobility of lower-limb amputees by providing a better-fitting prosthetic socket.

How similar studies have performed: While similar approaches to managing prosthetic fit have been explored, this specific technology for partial doffing is novel and has not been extensively tested.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Had trans-tibial amputation at least 18 months prior to enrollment
* Regularly wear a definitive prosthesis for at least 7 hours per week
* Have a residual limb length of at least 9 cm
* K2 or higher MFCL
* Able to walk continuously with a prosthesis for at least 2 minutes at a time
* Sit, stand, and negotiate a step of 5.0 cm

Participants involved remotely will have to meet the following inclusion criteria:

* Have a spare prosthesis
* No cognitive issues
* Good hand dexterity and strength (not frail)
* Capable of communication over a video Zoom conference call.

Exclusion Criteria:

* Current presence of skin breakdown
* Unable to satisfy inclusion criteria

Where this trial is running

Seattle, Washington

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Lower Limb Amputation Below KneeProsthetic SocketAmputeePin Lock Prosthetic Socket
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.