New surgical technique for gastric cancer treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates an innovative surgical method called Hao's Esophagogastrostomy by Fissure Technique (HEFT) for patients undergoing proximal gastrectomy due to gastric cancer. It is a multicenter, randomized, controlled trial comparing HEFT with traditional double-tract reconstruction. The study aims to assess nutritional status and safety outcomes post-surgery, building on previous findings that suggest HEFT is safe and feasible. The goal is to improve surgical outcomes and patient recovery through enhanced techniques.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. 18 years old ≤ 80 years old;
2. The primary tumor lesion is located in the upper part of the stomach or the esophagogastric junction (Siewert II or III), and it is expected that R0 surgical results can be obtained by performing proximal gastrectomy and D2 dissection；
3. The primary lesion was diagnosed as adenocarcinoma through endoscopic biopsy and histopathological examination;
4. If it is upper gastric adenocarcinoma, the clinical TNM staging based on imaging needs to be cT1N0M0. If it is ductal gastric junction adenocarcinoma, it needs to be cT1-3N0-1M0, and clinical imaging judgment shows no distant gastric lymph node metastasis；
5. Expected survival exceeds 6 months;
6. No history of upper abdominal surgery (excluding laparoscopic cholecystectomy);
7. No chemotherapy, radiotherapy, targeted therapy, immunotherapy, etc. were performed before surgery;
8. Preoperative ECOG (Eastern Cooperative Oncology Group) physical status score 0/1;
9. Preoperative ASA (American Society of Anesthesiologists) grading I-III ;
10. Good function of important organs;
11. Sign the patient's informed consent form

Exclusion Criteria:

1. Preoperative imaging examination suggests the fusion of enlarged lymph nodes (maximum diameter ≥ 3cm) in the area;
2. Pregnant and lactating women;
3. Suffering from other malignant tumors within 5 years;
4. Preoperative body temperature ≥ 38 ℃ or complicated with infectious diseases requiring systematic treatment;
5. Serious mental illness;
6. Severe respiratory diseases, FEV1\<50% of the expected value;
7. Severe liver and kidney dysfunction;
8. History of unstable angina or heart attack within 6 months;
9. History of cerebral infarction or cerebral hemorrhage within 6 months, excluding old intracavitary infarction;
10. Apply systemic corticosteroid therapy within one month;
11. Patients with complications of gastric cancer (bleeding, perforation, obstruction) requiring emergency surgery;
12. The patient has participated or is currently participating in other clinical studies (within 6 months)

Where it's running

• Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
  Shanghai, China Recruiting
• Huashan Hospital, Fudan University
  Shanghai, China Recruiting
• Second Department of Gastric Surgery, Fudan University Shanghai Cancer Center,
  Shanghai, China Recruiting

Study contacts

• Study coordinator: Hankun Hao, doctor
• Email: haohankun@163.com
• Phone: +86 18121186328

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• AI-assisted CT detection and staging of stomach cancer

  This project will test an AI tool that reads routine contrast-enhanced CT scans to detect stomach cancer and assign T1–T4 and N0–N3 stages before surgery.

  Recruiting The First Affiliated Hospital with Nanjing Medical University · Nanjing, Jiangsu · NCT07250347

• Single-port Robotic Removal of Gastric Tumor for Gastric Cancer

  This study tests whether a single-port robotic approach to removing gastric tumors is safe and feasible in adults with gastric cancer.

  Recruiting Daping Hospital and the Research Institute of Surgery of the Third Military Medical University · Chongqing, Chongqing Municipality and 1 other locations · NCT07237126

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.