New stress testing protocol to study heart issues in women with chest pain
DEVELOPMENT OF A NOVEL STRESS TESTING PROTOCOL TO DEFINE THE RELATIONSHIP BETWEEN CORONARY MICROVASCULAR DYSFUNCTION AND DIASTOLOGY IN WOMEN WITH ANGINA BUT NO EVIDENCE OF OBSTRUCTIVE CORONARY ARTERY DISEASE
This study is testing a new way to understand heart problems in women with chest pain but no blocked arteries, to see how their heart functions during stress.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | Female |
| Sponsor | Cedars-Sinai Medical Center Academic / other |
| Locations | 1 site (Los Angeles, California) |
| Trial ID | NCT02301663 on ClinicalTrials.gov |
What this trial studies
This study aims to explore the relationship between coronary microvascular dysfunction and heart relaxation in women experiencing chest pain but without obstructive coronary artery disease. It will involve 30 participants, including healthy individuals and women diagnosed with microvascular disease, who will undergo various stress maneuvers alongside advanced cardiac magnetic resonance imaging. The goal is to better understand the pathophysiology of microvascular coronary dysfunction and its impact on heart function.
Who should consider this trial
Good fit: Ideal candidates include women over 18 years old who experience chest pain and have been diagnosed with microvascular coronary dysfunction.
Not a fit: Patients with a history of cardiovascular, pulmonary, or neurological diseases, or those with hypertension, diabetes, or contraindications to cardiac MRI will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnosis and treatment options for women suffering from microvascular coronary dysfunction.
How similar studies have performed: While this approach is novel in its specific focus on women with microvascular dysfunction, similar studies have shown promise in understanding coronary microvascular disease.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Fully understanding and willing to undergo study procedures 2. Male or Female greater than or equal to 18 years of age 3. Understanding and willing to sign consent form. Exclusion Criteria: 1. History of cardiovascular, pulmonary, or neurological disease 2. Hypertension (sitting blood pressure \>140/90 mmHg, with measurements recorded on at least 2 occasions) 3. Diabetes 4. Unable to give informed consent; 5. Contra-indication to CMRI testing, including claustrophobia and metallic implants 6. Adherence or retention issues; 7. Women who are pregnant. 8. Allergy to animal dander.
Where this trial is running
Los Angeles, California
- Cedars-Sinai Medical Center — Los Angeles, California, United States (Recruiting)
Study contacts
- Principal investigator: Michael Nelson, PhD — Cedars-Sinai Medical Center
- Study coordinator: Barbra Streisand Women's Heart Center
- Phone: 310-423-9666
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.