New stress testing protocol to study heart issues in women with chest pain

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to explore the relationship between coronary microvascular dysfunction and heart relaxation in women experiencing chest pain but without obstructive coronary artery disease. It will involve 30 participants, including healthy individuals and women diagnosed with microvascular disease, who will undergo various stress maneuvers alongside advanced cardiac magnetic resonance imaging. The goal is to better understand the pathophysiology of microvascular coronary dysfunction and its impact on heart function.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Fully understanding and willing to undergo study procedures
2. Male or Female greater than or equal to 18 years of age
3. Understanding and willing to sign consent form.

Exclusion Criteria:

1. History of cardiovascular, pulmonary, or neurological disease
2. Hypertension (sitting blood pressure \>140/90 mmHg, with measurements recorded on at least 2 occasions)
3. Diabetes
4. Unable to give informed consent;
5. Contra-indication to CMRI testing, including claustrophobia and metallic implants
6. Adherence or retention issues;
7. Women who are pregnant.
8. Allergy to animal dander.

Where it's running

• Cedars-Sinai Medical Center
  Los Angeles, California, United States Recruiting

Study contacts

• Principal investigator: Michael Nelson, PhD — Cedars-Sinai Medical Center
• Study coordinator: Barbra Streisand Women's Heart Center
• Phone: 310-423-9666

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.