New model to study itch sensation using pruritogens
Repetitive Applications of Pruritogens and Effects of a Cutaneous-induced Pain Stimulation on Nonhistaminergic Itch Perception
This study is testing a new way to understand itch by seeing if using certain itch-causing substances multiple times makes healthy adults feel itchier than just using them once.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 26 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | Aalborg University Academic / other |
| Locations | 1 site (Aalborg, Aalborg) |
| Trial ID | NCT06328543 on ClinicalTrials.gov |
What this trial studies
This experiment aims to develop a novel itch model by examining the effects of multiple applications of pruritogens, specifically histamine and cowhage, on itch sensation. The hypothesis is that overlapping applications will produce a greater itch response compared to a single application. The study focuses on healthy adults aged 18-60 and seeks to better understand chronic itch, which affects a significant portion of the population and currently lacks effective treatments. By simulating clinical conditions, the research hopes to provide insights into the mechanisms of itch and potential therapeutic targets.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy men and women aged 18-60 who can speak and understand English.
Not a fit: Patients with skin diseases, neurological or immunological disorders, or those currently using medications that may affect the trial will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and treatment options for chronic itch conditions.
How similar studies have performed: While this approach is innovative, similar studies exploring itch mechanisms have shown promise, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy men and women * 18-60 years * Speak and understand Englis Exclusion Criteria: * Pregnancy or lactation * Drug addiction defined as any use of cannabis, opioids, or other addictive drugs * Previous or current history of neurological (e.g. neuropathy), immunological (e.g. asthma, immune deficiencies, arthritis), musculoskeletal (e.g. muscular pain in the upper extremities,), cardiac disorder, or mental illnesses that may affect the results * Lack of ability to cooperate * Current use of medications that may affect the trial such as antihistamines, antipsychotics, and pain killers, as well as systemic or topical steroids * Skin diseases (e.g. atopic dermatitis, pruritus nodularis, eczema, psoriasis) * Moles, scars, or tattoos in the area to be treated or tested. * Consumption of alcohol or painkillers 24 hours before the study days and between these * Acute or chronic pain * Participation in other trials within one week of study entry (four weeks in the case of pharmaceutical trials)
Where this trial is running
Aalborg, Aalborg
- Aalborg University — Aalborg, Aalborg, Denmark (Recruiting)
Study contacts
- Study coordinator: Silvia Lo Vecchio, PhD
- Email: slv@hst.aau.dk
- Phone: +4521397785
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.