New method for diagnosing keratoconus using advanced imaging technology

A Study on Evaluating the Consistency of CASIA2, Pentacam, and Corvis ST Measurement Parameters and the Diagnostic Efficacy of Early Keratoconus

Tianjin Eye Hospital · NCT06152484

This study is testing a new imaging device to see if it can better diagnose keratoconus by comparing its measurements with those from older devices.

Quick facts

Study typeObservational
Enrollment200 (estimated)
SexAll
SponsorTianjin Eye Hospital (other)
Locations1 site (Tianjin, Tianjin)
Trial IDNCT06152484 on ClinicalTrials.gov

What this trial studies

This observational study compares corneal topography measurements obtained from a novel optical coherence tomography device (CASIA2) with those from established devices like Pentacam and Corvis ST. The aim is to evaluate the effectiveness of these technologies in screening and diagnosing keratoconus, particularly focusing on their consistency in measuring corneal parameters such as curvature and thickness. By analyzing these different imaging techniques, the study seeks to improve diagnostic accuracy for keratoconus and its subclinical forms.

Who should consider this trial

Good fit: Ideal candidates include individuals with a best corrected visual acuity of 20/20 and no significant ocular diseases other than myopia and astigmatism.

Not a fit: Patients with other ocular diseases, previous ocular surgeries, or those who are pregnant or lactating may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to more accurate and early diagnosis of keratoconus, improving patient outcomes.

How similar studies have performed: While the approach is innovative, similar studies have shown promise in using advanced imaging techniques for diagnosing keratoconus.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. Best corrected visual acuity (BCVA) ≥ 20/20;
2. No other eye diseases except myopia and astigmatism;
3. The cornea was transparent, and there was no cloud or pannus;

Exclusion Criteria:

1. The presence of ocular diseases other than myopia and keratoconus;
2. Ocular trauma;
3. Previous ocular surgery; 4 Patients were required to stop wearing soft contact lenses for at least 2 weeks and rigid contact lenses for at least 4 weeks before examination; 6. Pregnant and lactating women;

Where this trial is running

Tianjin, Tianjin

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Scansys, Pentacam, Keratoconus, Subclinical Keratoconus, Scansys, Pentacam, Keratoconus, subclinical keratoconus

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.