New malaria control strategy for miners in the Guyanese Shield
Radical CUREfor MAlaria Among Highly Mobile and Hard-to-reach Populations in the Guyanese Shield
This study is testing a new way to control malaria among mobile miners in the Guyana Shield by providing health education and services where they gather.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 5000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Centre Hospitalier de Cayenne Academic / other |
| Locations | 2 sites (Oiapoque, Amapa and 1 other locations) |
| Trial ID | NCT05540470 on ClinicalTrials.gov |
What this trial studies
This study proposes a novel malaria control strategy targeting mobile miners, known as garimpeiros, in the remote regions of the Guiana Shield, which includes areas in Brazil, French Guiana, and Suriname. The intervention will take place in logistical hubs where these miners gather, allowing health services to reach them effectively. The approach combines health education with pre- and post-intervention surveys to evaluate its effectiveness. The study aims to address the challenges posed by the clandestine nature of mining activities and the mobility of the target population.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older who are actively involved in gold mining activities and have a history of malaria or are at risk of malaria transmission.
Not a fit: Patients who are not involved in gold mining activities or who do not meet the specific epidemiological criteria for malaria are unlikely to benefit from this study.
Why it matters
Potential benefit: If successful, this intervention could significantly reduce malaria transmission among hard-to-reach populations, improving health outcomes in these communities.
How similar studies have performed: While similar approaches targeting mobile populations have shown promise in other regions, this specific strategy is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria for PART and Malakit: * Be 18 years of age or older * Agree to participate in the study * Have an actual involvement in gold mining activities (having been to the garimpo in the last year or planning to enter the garimpo in the following month), regardless of country * No symptoms of malaria at the time of the inclusion visit * Weigh over 35 Kg Eligibility Criteria for PART - Module A -- Wish to take part in module A - Epidemiological and/or biological criteria in favour of a current asymptomatic carriage of P. vivax (blood stage or liver stage). At least one of the following conditions: * have a history of clinical malaria during the past 12 months * OR having a life-long malaria history AND have stayed for at least 1 week during the last 12 months in an area with extensive P. vivax transmission * OR have a positive P.vivax rapid serological test (if available) Eligibility Criteria for Malakit - Module B: * Wish to take part in module B * Plan to enter agarimpo located in French Guiana the following month Exclusion Criteria for PART - Module A: * Refuse to participate in an active follow-up during the 14 days following the start of treatment * Current pregnancy (declared or rapid urine test positive) or breastfeeding * Haemoglobinemia below 9 g/dL * G6PD activity below 70% (for simplicity G6PD activity of 6 UI/dL or below). * Have received a full course of tafenoquine within the last 3 months or a full course of primaquine in the last month. * Hypersensitivity or known contraindication to primaquine or tafenoquine or chloroquine * History of severe mental health disorder * Being positive for a malaria diagnostic test on the day of inclusion or currently taking anti-malarial treatment. Exclusion Criteria for Malakit - Module B: * Inability to self-test (perform and interpret an RDT) during training * Inability to understand and explain correctly what to do in case of malaria symptoms (tests and ACT posology) Inclusion criteria for Pre/post intervention surveys * Be 18 years of age or older * Agree to participate in the research * Having left a garimpolocated in French Guiana since maximum one week.
Where this trial is running
Oiapoque, Amapa and 1 other locations
- Josiane Muller — Oiapoque, Amapa, Brazil (Recruiting)
- Stephen vreden — Paramaribo, Suriname (Recruiting)
Study contacts
- Principal investigator: Stephen Vreden, PhD — Foundation for the Advancement of Scientific Research in Suriname
- Study coordinator: Maylis Douine, PhD
- Email: maylis.douine@ch-cayenne.fr
- Phone: 0594 39.53.88
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.