New lung imaging technique for patients receiving radiation therapy
Novel High Fidelity Functional Lung Imaging in Adults Undergoing Radiation Therapy to Assess for Radiation Pneumonitis
This study is testing a new lung imaging technique to see if it can help doctors spot early lung problems in adults getting radiation therapy for cancer.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 60 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Cedars-Sinai Medical Center Academic / other |
| Drugs / interventions | Radiation |
| Locations | 1 site (Los Angeles, California) |
| Trial ID | NCT02735746 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate a novel imaging technology called High Fidelity Functional Lung Imaging (HFFLI) to assess lung function in adults undergoing radiation therapy for various cancers. Participants will receive standard radiation treatment using the Varian TrueBeam system, while their lung function will be monitored through a combination of 4D CT scans, cone beam CT, and real-time fluoroscopic imaging. The goal is to determine if these imaging modalities can effectively identify early changes in lung function that may indicate a risk for radiation pneumonitis. The study will include adults over 18 years old who are receiving radiation therapy that involves the lungs.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old who are undergoing radiation therapy for lung, breast, or mediastinal cancer.
Not a fit: Patients with significant existing lung disease unrelated to cancer may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved early detection of radiation pneumonitis, allowing for timely interventions to protect lung function in cancer patients.
How similar studies have performed: While this approach is innovative, similar imaging techniques have shown promise in other studies, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults 18 years and older * Prospective subjects will have been referred to Radiation Oncology for treatment requiring the use of the Varian TrueBeam system, for radiation therapy of a cancer lesion in the chest wall, lung, breast, or mediastinum in which the radiation field will include a portion of lung * The subject is able to understand the risks, benefits, and possible alternatives to participation in the study, and is able to give both written and verbal voluntary informed consent Exclusion Criteria: * For any reason, including pregnancy, subject is considered by the Investigator to be an unsuitable candidate or is put at excess risk by the study procedures. * Significant existing lung disease, not related to cancer as determined by the PI's review of the patient's PFTs.
Where this trial is running
Los Angeles, California
- Cedars-Sinai Medical Center — Los Angeles, California, United States (Recruiting)
Study contacts
- Principal investigator: Stephen Shiao, MD, PhD — Cedars-Sinal Medical Center
- Study coordinator: Stephen Shiao
- Email: Stephen.Shiao@cshs.org
- Phone: 310-423-2836
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.