New CAR-macrophages tested on patient-derived breast cancer organoids

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational cohort collects tumor tissue and blood from adults with confirmed breast cancer who are undergoing surgery or biopsy. Tumor samples will be used to grow patient-derived organoids, three-dimensional tumor models that preserve features of each patient's cancer. Researchers will apply newly developed CAR-macrophages to these organoids to see whether the modified immune cells reduce tumor growth. Blood samples will be analyzed to characterize each patient's inflammatory status and to explore links between host factors and organoid responses.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male or female aged 18 years or more
* Histologically confirmed breast cancer at any stage
* Requiring surgery or tumor biopsy as standard of care
* Any or no systemic treatment
* Signed informaed consent
* Health insurance coverage

Exclusion Criteria:

* Opposed to biospecimen collection

Where it's running

• Oscar Lambret Center
  Lille, France Recruiting

Study contacts

• Study coordinator: Nawale HAJJAJI, MD PhD
• Email: n-hajjaji@o-lambret.fr
• Phone: +33 320295910

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.