Neutrophil-to-lymphocyte ratio in COPD flare-ups.
Official title: Neutrophil to Lymphocyte Ratio in Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Marker of Severity and Prognosis
Run by Ain Shams University · NCT07125352 · Data updated 2026-11-12
This project will test whether a routine blood measure called the neutrophil-to-lymphocyte ratio can help predict severity, outcomes, and treatment response in adults hospitalized with COPD flare-ups.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 190 (estimated) |
| Sponsor | Ain Shams University Academic / other |
| Locations | 1 site (Cairo, Abbasyea) |
| Status | Recruiting |
| Started | May 20, 2025 |
| Main results expected | December 2025 |
| Study ends | March 2026 |
| Registry record updated | August 15, 2025 |
| Trial ID | NCT07125352 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 and above admitted to the Chest Department at Ain Shams University with an acute COPD exacerbation defined by GOLD 2024 criteria are ideal candidates.
✕Probably not a fit
Patients with active cancer or hematologic disorders, outpatients with stable COPD, or those who refuse treatment are unlikely to benefit because their NLR may be confounded or they are not hospitalized.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a single-center observational study enrolling adults hospitalized with acute exacerbations of COPD at the Chest Department of Ain Shams University Hospitals. Researchers will calculate the neutrophil-to-lymphocyte ratio (NLR) from routine blood counts and correlate NLR values with measures of clinical severity, adverse outcomes, and response to treatment. Patients with malignancy or hematological disorders are excluded to avoid confounding of blood counts. The study aims to determine whether NLR, an inexpensive inflammatory marker, adds prognostic information in the hospital setting.
Why it matters
Potential benefit: If successful, measuring NLR could help doctors spot patients at higher risk during COPD flare-ups and make treatment decisions sooner.
How similar studies have gone: Previous studies have reported mixed results—some have linked higher NLR to worse outcomes in COPD and pneumonia, but findings remain inconsistent and debated.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 18 and above, Patients who will be admitted at the Chest department, Ain-Shams University Hospitals, diagnosed with AECOPD based on the Global Initiative for Chronic Obstructive Lung Disease 2024 criteria Exclusion Criteria: * Patients who refused treatment. * COPD patients with Malignancy, hematological disorders
Where it's running
-
Ain Shams University
Cairo, Abbasyea, Egypt Recruiting
Study contacts
- Study coordinator: Hieba G Ezzelregal, MD
- Email: hiebagamal24@med.asu.edu.eg
- Phone: 01002041611
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Non-invasive ventilation or CPAP for COPD with sleep apnea after a serious COPD flare
This study tests whether non-invasive ventilation (NIV) or CPAP can help adults with COPD and coexisting obstructive sleep apnea after a severe COPD flare requiring hospital care.
-
Collecting data on COPD exacerbations in hospitalized patients
This study is collecting health information and samples from 1,000 patients hospitalized for COPD flare-ups to help improve future treatments and understanding of the condition.
-
NAVA use in preterm neonates with respiratory distress syndrome
This trial tests whether neurally adjusted ventilatory assist (NAVA) helps preterm babies with respiratory distress syndrome breathe more easily than conventional ventilation.
-
Ruta C and Vitamin C in Sepsis: Adding antioxidants to standard care
This trial tests whether adding Ruta C (rutin plus vitamin C) or vitamin C alone to standard sepsis treatment helps adults in the ICU stay shorter and recover better.
-
Left DLPFC rTMS vs iTBS for emotional dysregulation, impulsivity, and NSSI in Borderline Personality Disorder
This trial tests whether high-frequency rTMS or intermittent theta-burst stimulation over the left DLPFC can help reduce emotional instability, impulsivity, and non-suicidal self-injury in adults with Borderline Personality Disorder.
-
Trimetazidine as an extra therapy for aluminum phosphide poisoning
In this pilot trial, adults with acute aluminum phosphide poisoning receive standard care plus trimetazidine to see if it helps save lives and improve recovery.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.