Clinical trial Recruiting at 1 site Observational Ages 18 and up

Neutrophil-to-lymphocyte ratio in COPD flare-ups.

Official title: Neutrophil to Lymphocyte Ratio in Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Marker of Severity and Prognosis

Run by Ain Shams University · NCT07125352 · Data updated 2026-11-12

This project will test whether a routine blood measure called the neutrophil-to-lymphocyte ratio can help predict severity, outcomes, and treatment response in adults hospitalized with COPD flare-ups.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment190 (estimated)
SponsorAin Shams University
Academic / other
Locations1 site (Cairo, Abbasyea)
StatusRecruiting
StartedMay 20, 2025
Main results expectedDecember 2025
Study endsMarch 2026
Registry record updatedAugust 15, 2025
Trial IDNCT07125352 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 18 and above admitted to the Chest Department at Ain Shams University with an acute COPD exacerbation defined by GOLD 2024 criteria are ideal candidates.

Probably not a fit

Patients with active cancer or hematologic disorders, outpatients with stable COPD, or those who refuse treatment are unlikely to benefit because their NLR may be confounded or they are not hospitalized.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-center observational study enrolling adults hospitalized with acute exacerbations of COPD at the Chest Department of Ain Shams University Hospitals. Researchers will calculate the neutrophil-to-lymphocyte ratio (NLR) from routine blood counts and correlate NLR values with measures of clinical severity, adverse outcomes, and response to treatment. Patients with malignancy or hematological disorders are excluded to avoid confounding of blood counts. The study aims to determine whether NLR, an inexpensive inflammatory marker, adds prognostic information in the hospital setting.

Why it matters

Potential benefit: If successful, measuring NLR could help doctors spot patients at higher risk during COPD flare-ups and make treatment decisions sooner.

How similar studies have gone: Previous studies have reported mixed results—some have linked higher NLR to worse outcomes in COPD and pneumonia, but findings remain inconsistent and debated.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients aged 18 and above, Patients who will be admitted at the Chest department, Ain-Shams University Hospitals, diagnosed with AECOPD based on the Global Initiative for Chronic Obstructive Lung Disease 2024 criteria

Exclusion Criteria:

* Patients who refused treatment.
* COPD patients with Malignancy, hematological disorders

Where it's running

  • Ain Shams University
    Cairo, Abbasyea, Egypt
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.