Neuroplasticity-targeted supplements for ADHD in children

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, placebo-controlled trial compares four groups of children with ADHD: gut-targeted supplements (prebiotics and probiotics), brain-targeted supplements (omega-3s and vitamin B1), both supplements, and placebo. The study will measure changes in ADHD symptoms with validated scales and look at biomarkers linked to neuroinflammation and neuroplasticity, such as IL-6, TNF-alpha, BDNF, SCFAs, and Claudin-5, from baseline to week 12. Sixty-eight participants will be enrolled and followed for 12 weeks to see if these supplements can improve behavioral scores and biological markers. The research aims to clarify whether targeting gut health and brain chemistry can offer additional benefit beyond standard ADHD management.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* DSM-5 confirmed ADHD diagnosis
* Age 6-12 years
* Medication-free or on stable stimulant medication (≥1 month)

Exclusion Criteria:

* Antibiotic use in last 4 weeks
* Gastrointestinal disorders
* Neurological comorbidities (e.g., epilepsy)
* Severe food allergies

Where it's running

• Khyber Teaching Hospital
  Peshawar, Kpk, Pakistan Recruiting

Study contacts

• Principal investigator: Dr Dur E Shawar, PhD* — Khyber Medical University Peshawar, Pakistan
• Study coordinator: Dr Dur E Shawar, PhD*
• Email: shehwar88@gmail.com
• Phone: 03348405894

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.