Neuromuscular electrical stimulation to prevent exercise resistance
Use of Neuromuscular Electrical Stimulation to Prevent Exercise Resistance
This will try 100 minutes of electrical muscle stimulation in regularly active adults to see if it prevents losing exercise-related improvements in fat metabolism after short sedentary periods.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 40 Years |
| Sex | All |
| Sponsor | Colorado State University Academic / other |
| Locations | 1 site (Fort Collins, Colorado) |
| Trial ID | NCT07161648 on ClinicalTrials.gov |
What this trial studies
Exercise resistance refers to the loss of exercise-induced improvements in fat metabolism that can occur after prolonged sedentary behavior between workouts. The protocol induces exercise resistance by having participants abstain from activity other than exercise for short periods, and on a separate visit replaces that inactivity with 100 minutes of neuromuscular electrical stimulation (NMES). Metabolic responses to a meal will be measured to determine whether NMES preserves the normal post-exercise fat metabolism. Participants are regularly active adults who can complete treadmill exercise and must attend in-person visits at the Fort Collins site.
Who should consider this trial
Good fit: Ideal candidates are regularly active adults (≥30 minutes per day, ≥3 days/week over the past year) who can complete an hour of treadmill exercise and attend in-person visits at Colorado State University's Fort Collins campus.
Not a fit: People with cardiopulmonary disorders, current cardio-pulmonary medications, pregnancy or breastfeeding, or injuries preventing treadmill exercise are unlikely to benefit or be eligible.
Why it matters
Potential benefit: If successful, NMES could help people maintain the metabolic benefits of exercise despite brief sedentary periods, potentially reducing cardiometabolic risk.
How similar studies have performed: Prior studies show NMES increases muscle contractions and energy expenditure, but using NMES specifically to prevent exercise resistance is a novel approach that has not been proven.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Regularly active (more than 30 minutes of exercise per day, 3 days per week, over the previous 12 months) * Ability to complete at least one hour of treadmill exercise (i.e. jogging/running), * Willing to abstain from caffeine and alcohol for 24-hours prior to three different study visits * Competency in English Exclusion Criteria: * Current or previous injuries that may hinder a participant's ability to exercise on a treadmill * A history of cardiopulmonary disorder that may be contra-indicative to treadmill exercise * Current use of cardio-pulmonary medication to treat a cardio-pulmonary condition * Currently breastfeeding * Pregnancy
Where this trial is running
Fort Collins, Colorado
- Colorado State University — Fort Collins, Colorado, United States (Recruiting)
Study contacts
- Principal investigator: Christopher Bell, Ph.D. — Colorado State University
- Study coordinator: Christopher Bell, PhD
- Email: christopher.bell@colostate.edu
- Phone: 970-491-7522
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.