Neuromodulation for motor recovery after stroke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The CERSTIM study investigates the effects of transcranial alternating current stimulation (tACS) on the cerebello-motor network in stroke patients. Using a crossover design, the study tests two gamma band frequencies and a placebo to assess their impact on motor recovery. Behavioral data, functional MRI, and electroencephalography will be utilized to understand the mechanisms of tACS. Healthy participants will also be included to provide comparative insights.

Why it matters

Who can join: the full rules

PATIENTS

Inclusion Criteria:

* Male or female aged 18 years or older on the day of inclusion.
* Affiliated with a social security system, Universal Health Coverage (CMU), or any equivalent scheme.
* Ischemic stroke or intraparenchymal hematoma that occurred more than 6 months ago, with no upper time limit.
* Motor deficit of the upper limb confirmed by the ARAT scale, with the ability to grip and press on a tablet.
* stroke lesion not affecting the motor cortex in the hand knob area.

Exclusion Criteria:

\-- Pregnant and breastfeeding women

* Total paralysis of the affected hand
* Conditions that are life-threatening or could compromise follow-up during the study period
* Contraindications to MRI and tACS (ferromagnetic surgical clips, ocular implants, intraocular or nervous system metallic foreign bodies, implants or metallic objects likely to concentrate the radiofrequency field, cochlear implants, brain or cardiac stimulators, presence of a craniotomy scar)
* Participation in another biomedical study focused on motor or overall recovery during the same period, or current exclusion period from another biomedical study

HEALTHY

Inclusion Criteria:

* Male or female aged 18 years or older on the day of inclusion.
* Affiliated with a social security system, Universal Health Coverage (CMU), or any equivalent scheme.

Non inclusion criteria

\-- Pregnant and breastfeeding women

* Conditions that are life-threatening or could compromise follow-up during the study period
* Contraindications to MRI and tACS (ferromagnetic surgical clips, ocular implants, intraocular or nervous system metallic foreign bodies, implants or metallic objects likely to concentrate the radiofrequency field, cochlear implants, brain or cardiac stimulators, presence of a craniotomy scar)
* Participation in another biomedical study during the same period, or current exclusion period from another biomedical study

Where it's running

• ICM_ Institut du Cerveau et de la Moelle épinière, Hôpital Pitié, 47 Bd de l'Hôpital
  Paris, France Recruiting
• ToNIC - Toulouse neuro Imaging center (Inserm)Pavillon Baudot
  Toulouse, France Not yet recruiting

Study contacts

• Principal investigator: Charlotte ROSSO, MD PHD — Institut National de la Santé Et de la Recherche Médicale, France
• Study coordinator: Charlotte ROSSO, MD PhD
• Email: charlotte.rosso@aphp.fr
• Phone: +33142162103

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Deep phenotyping to explore recovery in young adults after stroke

  This project will test whether a detailed health and sample-collection approach (deep phenotyping) is practical and acceptable for people aged 18–55 who have had a stroke.

  Recruiting The Florey Institute of Neuroscience and Mental Health · Heidelberg, Victoria and 1 other locations · NCT07019493

• Stem cell therapy for chronic stroke recovery

  This study is testing whether using a patient's own stem cells can help people with long-term stroke recovery feel better and improve their daily functioning.

  Recruiting Phase 2 Hokkaido University Hospital · Sapporo, Hokkaido · NCT06752720

• AI-based tools to help diagnose, treat and predict stroke outcomes across multiple hospitals

  This study tests AI-powered tools on real-world stroke patients to see if they can improve pre-hospital triage, diagnosis, and outcome prediction while data stay securely within each hospital.

  Recruiting at 2 sites Hospital Universitari Vall d'Hebron Research Institute · Leuven and 6 other locations · NCT07924371

• Web-based therapy using action observation and mirror therapy for arm weakness after stroke

  This trial tests whether a mobile telerehabilitation app delivering action observation therapy (AOT) alone or combined AOT with mirror therapy (AOT-MT) can improve upper limb function in people with subacute stroke.

  Recruiting Chang Gung Memorial Hospital · Taoyuan · NCT07921108

• Remote Ischaemic Conditioning for Fatigue After Stroke 2

  Aat least 12 weeks after stroke, adults with post-stroke fatigue will try a simple hand-arm cuff treatment at home to see if it helps reduce fatigue.

  Recruiting Phase 2 Sheffield Teaching Hospitals NHS Foundation Trust · Sheffield, South Yorkshire · NCT07914647

• Dual-task balance training plus computer-based cognitive training after stroke

  In adults who recently had a stroke, the study tests whether adding computerized cognitive exercises to balance training improves balance and other recovery outcomes.

  Recruiting Matia Foundation · San Sebastián, GUIPUZCOA · NCT07913620

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.