Neurofeedback for Veterans with Suicidal Thoughts
Reducing Suicide-Specific Rumination in Veterans Using Real-time Functional Magnetic Resonance Imaging Neurofeedback
This study is testing whether a new brain training method can help veterans with suicidal thoughts learn to change their thinking patterns and feel better.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 15 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | VA Office of Research and Development Federal |
| Locations | 1 site (The Bronx, New York) |
| Trial ID | NCT06481033 on ClinicalTrials.gov |
What this trial studies
This study explores the use of real-time functional magnetic resonance imaging (rt-fMRI) neurofeedback to help veterans learn to modulate brain activity associated with suicidal thoughts and rumination. By targeting specific brain regions involved in repetitive self-critical thinking, the study aims to reduce suicide-specific rumination in veterans at elevated risk of suicide. The feasibility and acceptability of this innovative approach will be assessed in a small group of participants, with pre- and post-treatment evaluations to measure changes in suicidal thoughts. The study addresses a critical gap in treatment options for veterans facing mental health challenges.
Who should consider this trial
Good fit: Ideal candidates for this study are U.S. military veterans aged 18-65 with a history of suicide attempts and elevated levels of suicidal rumination.
Not a fit: Patients currently at imminent risk of suicide or with severe psychiatric disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could provide veterans with effective strategies to manage suicidal thoughts and reduce the risk of suicide.
How similar studies have performed: While the use of rt-fMRI neurofeedback is a novel approach, previous studies have shown promise in using neurofeedback for various mental health conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * U.S. military veteran between 18-65 years old * negative pregnancy test on MRI scan days * score greater than or equal to 10 on the Suicide Rumination Scale * clinically stabilized on psychotropic medications * engaged in mental health care treatment * able to provide written, informed consent Exclusion Criteria: * no major medical or neurological disorders that could interfere with treatment * moderate or severe traumatic brain injury * current imminent suicide risk, as determined through psychiatric interview, responses to C-SSRS, and clinical judgment of the assessor * any current psychotic disorder * MRI contraindications * any substance use disorder for substances other than cannabis or alcohol (mild alcohol or cannabis use disorder does not exclude participants but moderate or severe alcohol or cannabis substance use disorder is disqualifying) * pregnant or trying to become pregnant
Where this trial is running
The Bronx, New York
- James J. Peters VA Medical Center, Bronx, NY — The Bronx, New York, United States (Recruiting)
Study contacts
- Principal investigator: Philip R Szeszko, PhD — James J. Peters Veterans Affairs Medical Center
- Study coordinator: Philip R Szeszko, PhD
- Email: Philip.Szeszko@va.gov
- Phone: (718) 584-9000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.