NeuroCare Community Project: Early Alzheimer's Detection in Hong Kong

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, community-based observational cohort study in Hong Kong aimed at identifying biomarkers and imaging patterns that distinguish clinically normal individuals, MCI, and AD. It will compare clinical assessments, diagnoses, and blood biomarker panels against MRI and PET imaging as reference standards. The study plans to pre-screen about 6,000 elderly individuals and enroll around 2,500 participants for cross-sectional analysis, with 2–3 years of longitudinal follow-up over a 5-year period. The project will explore novel blood and imaging markers for AD diagnosis and progression, with data collection spanning clinical, cognitive, biomarker, and neuroimaging metrics.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Mentally capable of providing informed consent, with or without an informant present
* Willing and able to undergo blood draw and complete study related assessments; willing to be contacted for follow-up

Exclusion Criteria:

* Lacks capacity to consent even with an informant present
* Refuses or is unable to provide blood samples or complete essential assessments
* Currently enrolled in another clinical trial that could interfere with this study
* Known illness that prevents longitudinal follow up or uncontrolled medical illness such as neurodevelopmental disorder, neurodegenerative disease, epilepsy, central nervous system infection, neuroinflammatory diseases, brain tumor, cerebrovascular diseases, history of major psychiatric illness, history of major head injury with altered consciousness, sexually transmitted disease including HIV and syphilis, visual and auditory disability, history of alcohol dependence, substance use disorder, systemic autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis, or malignancy.
* Active delirium or evidence of reversible/secondary causes of cognitive impairment (e.g., vitamin B12 deficiency, hypothyroidism) until treated/ stabilized

Where it's running

• Hong Kong University of Science and Technology
  Hong Kong, China Recruiting

Study contacts

• Principal investigator: Nancy Ip, PhD — Hong Kong University of Science and Technology
• Study coordinator: Nancy Ip, PhD
• Email: boip@ust.hk
• Phone: +852-23587304

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• One-day exercise test to see how brain and body react in epilepsy, cognitive disorders, Parkinson's, dementia, and related conditions

  A one-day study tests how an acute bout of exercise changes brain function and bodily signals in people with certain neurological conditions compared with healthy individuals.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT07883720

• Gut and Oral Microbiome and Cognitive Health in Aging

  This study tests whether differences in gut and mouth bacteria are linked to cognitive health in adults across ages and cognitive status.

  Recruiting University of South Florida · Tampa, Florida · NCT07799402

• Gut methane and Parkinson's: measuring if a probiotic helps people with Parkinson's, REM sleep behavior disorder, or cognitive concerns

  This study tests whether a probiotic containing Limosilactobacillus reuteri can help people with Parkinson's disease, those at high risk for PD, and related cognitive issues by potentially improving gut methane levels and overall symptoms.

  Recruiting University of Cambridge · Cambridge, CB2 · NCT07786116

• AI-supported sleep program for people with mild cognitive impairment or dementia

  A small randomized trial tests an AI-assisted behavioral sleep program to help people with mild cognitive impairment or mild dementia who have sleep problems.

  Recruiting The Hong Kong Polytechnic University · Kowloon, Hung Hom · NCT07784946

• Blood tests using plasma biomarkers to diagnose and track Alzheimer’s disease

  A large, year-long study in Milan is testing whether blood markers can help diagnose Alzheimer’s and predict how it will progress in people with memory concerns.

  Recruiting IRCCS San Raffaele · Milan, Milano · NCT07717567

• Music for Pain and Dementia: Group Drumming for people with early dementia and their caregivers

  This study tests whether group drumming can reduce pain and change brain activity in people with mild dementia or mild cognitive impairment and in their caregivers.

  Recruiting Yale University · New Haven, Connecticut · NCT07602283

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.