Neurobehavioral Therapy for treating Functional Neurological Disorder

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot randomized clinical trial aims to evaluate the effectiveness of Neurobehavioral Therapy (NBT) in treating motor functional neurological disorder (mFND). Participants will be randomly assigned to receive either 12 weekly sessions of NBT alongside standard medical care or continue with standard medical care alone. The study will assess the impact of NBT on mFND symptoms and co-occurring issues through self-report surveys and in-clinic visits over a 12-month period. A total of 40 participants aged 18 to 70 will be enrolled at Rhode Island Hospital.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Individuals diagnosed with Motor Functional Neurological Disorder (mFND)
* Individuals aged 18-100 years
* At least 1 mFND symptom during the year prior to enrollment

Exclusion Criteria:

* Current or past year self-injurious behavior
* Current suicidality (PHQ-9 question 9 rated as 1 or above)
* Current or past year psychosis
* Pending litigation or current application for long term disability
* Active substance or alcohol use disorders (dependence), at the discretion of the investigator if they preclude participation in the study
* Serious illness requiring systemic treatment or hospitalization; the participant either completes therapy or is clinically stable on therapy, for at least 30 days prior to study entry
* Inability to fill out the self-report surveys
* Inability or unwillingness to participate in NBT and assigned homework
* Currently enrolled in NBT aimed at mFND

Where it's running

• Rhode Island Hospital
  Providence, Rhode Island, United States Recruiting

Study contacts

• Principal investigator: W. Curt LaFrance Jr, MD, MPH — Brown University Health
• Study coordinator: Alexis Sr. Clinical Research Assistant
• Email: ademarco@brownhealth.org
• Phone: 401-606-4651

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• One-day exercise test to see how brain and body react in epilepsy, cognitive disorders, Parkinson's, dementia, and related conditions

  A one-day study tests how an acute bout of exercise changes brain function and bodily signals in people with certain neurological conditions compared with healthy individuals.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT07883720

• Clear, empathetic diagnosis guidance for people with functional neurological movement disorders

  This study tests whether a structured, empathetic explanation of the diagnosis helps patients with functional neurological movement disorders understand their condition and feel more satisfied with care.

  Recruiting Medical University of Graz · Graz · NCT07588282

• Acute functional neurological symptoms in emergency patients

  This project will look back at emergency patients with functional neurological disorder to see how often they present, what symptoms and diagnostic pathways they had, and how hospital resources were used.

  Recruiting University Hospital, Basel, Switzerland · Basel · NCT07538414

• Theta-burst rTMS to improve self-reported motor symptoms in functional neurological disorder

  This project will try neuronavigated theta-burst repetitive transcranial magnetic stimulation (rTMS) to see if adults with motor functional neurological disorder feel their symptoms have improved.

  Recruiting Hospital Center Guillaume Régnier · Rennes · NCT07527403

• Feasibility of using thigh-worn trackers to measure daily activity in people with Functional Neurologic Disorder

  We’re testing if a thigh-worn accelerometer can reliably track daily activity in people with FND and see how those activity measures relate to clinician and patient reports.

  Recruiting University of Colorado, Denver · Denver, CO · NCT07478666

• Creating a treatment program for functional neurological disorder

  This study is trying to create a new treatment plan for people with functional neurological disorder by bringing together different types of therapy to see if it helps both kids and adults feel better.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT06362161

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.