Clinical trial Recruiting at 1 site Interventional Ages 18 to 65

Nerve conduction testing for people with rheumatoid arthritis taking baricitinib

Official title: Nerve Conduction Study for Assessment of Peripheral Neuropathy in Rheumatoid Arthritis Patients on the Janus Kinase Inhibitor Baricitinib

Run by Sohag University · NCT06977035 · Data updated 2026-11-12

This project will test whether nerve conduction testing detects peripheral nerve changes in adults with rheumatoid arthritis who are taking baricitinib.

Quick facts

Study typeInterventional
Ages18 Years to 65 Years
SexAll
Enrollment60 (estimated)
SponsorSohag University
Academic / other
Drugs / interventionsBaricitinib
Locations1 site (Sohag)
StatusRecruiting
StartedMay 5, 2025
Main results expectedNovember 5, 2025
Study endsJune 2026
Registry record updatedMay 12, 2026
Trial IDNCT06977035 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 18 to 65 with rheumatoid arthritis who meet the 2010 ACR/EULAR criteria, are taking baricitinib, and can cooperate with testing are the ideal candidates.

Probably not a fit

People younger than 18 or older than 65, or those with other causes of neuropathy such as diabetes or other rheumatologic/collagen diseases, are unlikely to benefit from the findings.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with rheumatoid arthritis who meet standard classification criteria and are taking the JAK inhibitor baricitinib will undergo nerve conduction studies to measure sensory nerve action potentials (SNAPs) and compound muscle action potentials (CMAPs). The testing will characterize sensory and motor nerve function along peripheral nerve pathways. Eligible, consenting participants seen at the site will have standardized NCS procedures performed and results compared to expected normative values and known neuropathy patterns. The protocol excludes patients with other causes of neuropathy such as diabetes or other rheumatologic/collagen diseases to isolate findings related to RA and baricitinib exposure.

Why it matters

Potential benefit: If successful, the work could help detect early or subclinical peripheral nerve changes in patients on baricitinib so clinicians can monitor or adjust treatment sooner.

How similar studies have gone: Nerve conduction studies are a well-established method for detecting peripheral neuropathy, but their specific use to characterize neuropathy in patients on baricitinib is relatively untested.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. Patients fulfill the 2010 ACR/EULAR classification criteria of RA
2. Age above 18 years old.
3. Patient cooperative and can answer questions

Exclusion Criteria:

1. Other rheumatologic or collagen diseases.
2. Age below 18 years and above 65 years.
3. Uncooperative patients.
4. Patients with other causes of peripheral neuropathy as Diabetes mellitus.

Where it's running

  • Sohag University Hospital
    Sohag, Egypt
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.