Neoven (Ruscus aculeatus 225 mg) capsules for adults with stage II–III hemorrhoids

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults aged 18–45 with symptomatic stage II–III hemorrhoids are enrolled and receive either Neoven 225 mg capsules containing Ruscus aculeatus L. or a matching placebo. The trial tracks symptom changes and safety using clinical examination (including anoscopy/rectoscopy performed within four weeks of baseline) and patient-reported outcomes. Key exclusions include prior hemorrhoid surgery, recent injection treatments, perianal sepsis, inflammatory bowel disease, colorectal malignancy, and other anorectal pathology. The study is conducted at Sultan Abdulhamid Training and Research Hospital in Istanbul with industry collaboration.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients between the ages of 18-45 with complaints (symptomatic) consistent with hemorrhoidal disease
2. Patients with Stage II and III hemorrhoids according to the Goligher Hemorrhoid Rating system using physical examination (digital rectal examination, anoscopy/rectoscopy performed within a maximum of four weeks before the examination)
3. Patients who have signed the Informed Consent Form

Exclusion Criteria:

* Patients aged \<18 and \>45 years
* Stage I and IV hemorrhoids according to the Goligher Hemorrhoid Rating system
* Surgery for hemorrhoids at any time
* Injection treatment for multiple hemorrhoids in the last 3 years
* Perianal sepsis, inflammatory bowel disease, colorectal malignancy, or pre-existing sphincter injury within the last 3 years
* Immunodeficiency
* In addition to hemorrhoids, patients with anal fissures and perianal fistulas detected by simultaneous physical examination or anoscopy/rectoscopy

Where it's running

• Sultan Abdulhamid Training and Research Hospital
  Istanbul, Turkey (Türkiye) Recruiting

Study contacts

• Principal investigator: Haluk Kerim KARAKULLUKCU, MD — Sultan Abdulhamid Training and Research Hospital
• Study coordinator: Haluk Kerim Karakullukcu, MD
• Email: halukkarakkulukcu@gmail.com
• Phone: +905384357181

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.