Neoantigen vaccines for treating esophageal cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the efficacy and safety of a neoantigen-loaded dendritic cell vaccine as a consolidation therapy for patients with locally advanced, unresectable esophageal squamous cell carcinoma (ESCC) following radical chemoradiotherapy. The study aims to determine if combining this vaccine with immune checkpoint inhibitors can improve overall survival and quality of life. Participants will undergo diagnostic endoscopy and provide fresh tumor tissue samples for neoantigen identification. The trial will assess various endpoints, including overall survival rates, progression-free survival, and quality of life metrics.

Why it matters

Who can join: the full rules

Inclusion Criteria:

A. Age 18-80 years

B. Locally advanced unresectable ESCC patients after radical treatment (radical chemoradiotherapy or chemoradiation); including:

* Cervical esophageal segment, T4, supraclavicular lymph node metastasis, or inability/refusal to undergo surgery due to personal reasons (refer to hospital below); ② Failure of neoadjuvant or conversion therapy; ③ Postoperative local recurrence, unresectable (target lesion present). C. No evidence of tumor recurrence or metastasis 2-3 weeks after radical treatment D. Ability to provide fresh tumor tissue samples (baseline) E. Normal major organ function F. Performance status (PS) score ≤ 1 G. Patients of childbearing potential must use contraception H. Voluntary participation with signed informed consent

Exclusion Criteria:

A. History of fistula caused by primary tumor invasion B. High risk of gastrointestinal bleeding, esophageal fistula, or esophageal perforation C. Poor nutritional status D. Immune-related adverse events during prior radical treatment, such as Grade ≥3 pneumonitis, myocarditis, etc.

E. Signs and symptoms of interstitial diseases F. Presence of any severe and/or uncontrolled medical conditions G. Presence of concurrent malignancies H. Presence of other autoimmune diseases, or prolonged use of immunosuppressants or steroids I. Difficulty in patient communication or inability to comply with long-term follow-up J. Other conditions deemed unsuitable by the investigator

Where it's running

• West China Hospital of Sichuan University
  Chengdu, Please Select, China Recruiting

Study contacts

• Principal investigator: zhenyu ding, MD — West China Hospital of Sichuan University, ChengDu, China
• Study coordinator: zhenyu ding, MD
• Email: dingzhenyu@scu.edu.cn
• Phone: +86 028-854-22562

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Neoadjuvant CTLA-4 and PD-1 blockade with chemoradiotherapy for locally advanced ESCC

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• PD-1 inhibitors with local therapy at different timings in oligometastatic ESCC

  This study tests whether giving local radiotherapy at different times around PD-1 inhibitor therapy helps people with oligometastatic esophageal squamous cell carcinoma.

  Recruiting Fudan University · Shanghai, Shanghai Municipality · NCT07697859

• Adebrelimab plus chemotherapy before surgery for borderline-resectable esophageal squamous cell carcinoma

  This trial tests whether adding adebrelimab to chemotherapy given before surgery can shrink borderline-resectable ESCC enough to allow curative tumor removal.

  Recruiting Phase 2 Sun Yat-sen University · Guangzhou, Guangdong · NCT07638436

• Adebrelimab with neoadjuvant chemoradiotherapy for esophageal squamous cell carcinoma

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  Recruiting Phase 2 Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong · NCT07595770

• Starting chemo plus PD-1 immunotherapy before radiation versus giving chemo during radiation for unresectable locally advanced esophageal squamous cell carcinoma

  This trial sees if giving three cycles of chemotherapy with a PD-1 immunotherapy before radiation, followed by maintenance immunotherapy, works better than giving chemotherapy at the same time as radiation followed by the same maintenance for people with unresectable locally advanced esophageal squamous cell carcinoma.

  Recruiting Phase 2 Second Affiliated Hospital of Zunyi Medical University · Zunyi, Guizhou · NCT07559045

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.